1.Grade 2007, Seven-year System; 2.Department of Physiology,
China Medical University, Shengyang 110001, China

Tight junction is the structural and functional basis of blood brain barrier. It is a complicated cyto-system with auto-regulatory function. Recent research has found that ischemia reperfusion has an impact on the structure and distribution of tight junction via different pathways. Clarification of the molecular structure, the alteration of tight junction during cerebral trauma and the underlying regulatory mechanism of blood brain barrier permeability may provide a novel idea for the treatment and prevention of cerebral trauma.