International Journal of Pathology and Clinical Me 2010, 30(1) 65- DOI:   10.3969/j.issn.16732588.2010.  ISSN: 1673-2588 CN: 43-1458/R
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Keywords
DandyWalker syndrome;multifactorial genetic disease;brain dysplasia;hearing loss
Authors
PubMed

Progress in the study on pathogenic genes of DandyWalker syndrome

LAI Ruosha, XIE Dinghua

Department of Otorhinolaryngology Head and Neck Surgery, Second Xiangya Hospital , Central South University, Changsha 410011, China

Abstract：

DandyWalker syndrome is a rare congenital brain dysplasia. It is a multifactorial genetic disease with different genetic patterns and a diversity of clinical manifestations. Genetic linkage analysis and gene mapping revealed the close correlations between that the variety of phenotypes and genotypes in DandyWalker syndrome. It will help to elucidate the molecular basis of pathogenesis for DandyWalker syndrome, and provide a guide for the gene diagnosis and treatment.

Keywords： DandyWalker syndrome;multifactorial genetic disease;brain dysplasia;hearing loss  
Received 2009-10-23 Revised 2010-01-23 Online:  
DOI: 10.3969/j.issn.16732588.2010.
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Email: huaxie@2188.cn
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