International Journal of Pathology and Clinical Me 2010, 30(1) 53- DOI:   10.3969/j.issn.16732588.2010.  ISSN: 1673-2588 CN: 43-1458/R
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Keywords
microRNA;cancer;expression regulation
Authors
PubMed

Advance in the research on miRNA and tumor

TANG Yi, SU Qi

Cancer Research Institute, University of South China, Hengyang Hunan 421001, China

Abstract：

MicroRNAs (miRNA) are a class of ～22nucleotides noncoding RNAs, which participate in regulating gene expression at the posttranscriptional level. Posttranscriptional silencing of target genes by miRNA occurs either by targeting specific cleavage of mRNA or by targeting specific protein synthesis. There are significantly differential expressions of miRNAs between normal tissues and cancers， suggesting that miRNAs may participate in cancer development and progression. In this review，we will discuss the progress in the study on microRNA in cancer.

Keywords： microRNA;cancer;expression regulation  
Received 2009-12-03 Revised 2010-01-20 Online:  
DOI: 10.3969/j.issn.16732588.2010.
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Corresponding Authors:
Email: suqi1945@yahoo.com.cn
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