Abstract

International Journal of Pathology and Clinical Me 2010, 30(1) 39- DOI: 10.3969/j.issn.16732588.2010. ISSN: 1673-2588 CN: 43-1458/R

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	Keywords
	breast neoplasms;DNAJB6 protein;immunohistochemistry
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Protein expression of DNAJB6 and its clinical significance in breast cancer

CHEN Yongwu1, WANG Chuan2, FU Fangmeng2, XU Guoxi1, YANG Faduan3, KANG Deyong3

1. Department of Oncology, Clinical Academy of Fujian Medical University Union Hospital，Fuzhou 350004; 2. Department of Oncology, Fujian Medical University Union Hospital，Fuzhou 350004; 3. Department of Pathology, Fujian Medical University Union Hospital，Fuzhou 350004，China

Abstract：

Objective To investigate the protein expression of DNAJB6 and its clinical significance in breast cancer. MethodsImmunohistochemical staining was performed to detect the expression of DNAJB6 protein in 78 specimens of breast cancer, and the correlation between the expression of DNAJB6 protein and the clinicopathologic characteristics was analyzed.ResultsAmong 78 samples 49(62.8%) were at low expression level of DNAJB6 protein. The expression level of DNAJB6 protein was negatively correlated with the size of the tumor and histological grade in breast cancer (rs=-0.254 and rs=-0.293 respectively，P＜0.05). Conclusion The low expression level of DNAJB6 protein is associated with the malignant biological characteristics of breast cancer.

Keywords： breast neoplasms;DNAJB6 protein;immunohistochemistry

Received 2009-11-04 Revised 2010-01-08 Online:

DOI: 10.3969/j.issn.16732588.2010.

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Email: chuanwang1968@hotmail.com

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