1.First Department of Clinical Medicine, School of Medicine; 2.BA De-Nian Medical Class, School of Medicince;
3.Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou Zhejiang 310058, China

FAP is an autosomal dominant disease caused by mutations of APC gene. Recently hyperlipidemia is thought as one of the extracolonic complications of FAP and the symptoms of hyperlipidemia have been seen in the classical FAP mouse model with Apc gene mutation. The relations among hyperlipidemia, FAP and APC gene mutation are discussed extensively in this review. The purpuse is to provide the valuable information for preventing and treating the FAP patients.