International Journal of Pathology and Clinical Me 2009, 29(6) 487-489 DOI:     ISSN: 1673-2588 CN: 43-1458/R
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Keywords
non-small-cell lung cancer；excision repair cross-complementation group 1；
polymorphism;single nucleotide
Authors
PubMed

Role of ERCC1 gene in non-small cell lung cancer

DUAN Xunhuang1, ZHONG Jun2

1.Medical Graduate School of Nanchang University, Nanchang 330031; 2.Department of Radiation Oncology,
Jiangxi Tumor Hospital, Nanchang 330029，China

Abstract：

Chemotherapy is one of the principal means of combined therapy in non-small cell lung cancer, but drug resistance is the major factor that impairs the therapeutic effect. Excision repair cross-complementation group 1 (ERCC1) is the key gene for nucleotide excision repair. Its expression and polymorphisms are related to platinum resistance, which may affect the chemotherapy sensititivity and efficacy for non-small cell lung cancer.

Keywords： non-small-cell lung cancer；excision repair cross-complementation group 1；
polymorphism;single nucleotide  
Received 2009-09-06 Revised 2009-09-21 Online:  
DOI:
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Email: zhongjun@medmail.com.cn
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