紧密连接是血脑屏障的结构功能基础，它是一个复杂的、具有主动调节性的细胞系统。近来的研究表明缺血再灌注通过各种途径影响紧密连接的结构和分布。探讨血脑屏障连接复合体的分子结构、在脑损伤时的变化以及对血脑屏障通透性调节的可能机制为脑损伤的临床防治提供了一个全新的思路。

Tight junction is the structural and functional basis of blood brain barrier. It is a complicated cyto-system with auto-regulatory function. Recent research has found that ischemia reperfusion has an impact on the structure and distribution of tight junction via different pathways. Clarification of the molecular structure, the alteration of tight junction during cerebral trauma and the underlying regulatory mechanism of blood brain barrier permeability may provide a novel idea for the treatment and prevention of cerebral trauma.

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