| ［1］Mitsui K, Tokuzawa Y, Itoh H, et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells［J］. Cell, 2003, 113(5): 631642.
［2］Chambers I, Colby D, Robertson M, et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells［J］. Cell, 2003, 113(5): 643655.
［3］Huntly BJ,Gilliland DG.Cancer biology: summing up cancer stem cells［J］. Nature, 2005, 435(7046): 11691170.
［4］Yamaguchi S,Kimura H,Tada M,et al. Nanog expression in mouse germ cell development［J］. Gene Expr Patterns, 2005, 5(5): 639646.
［5］Hart AH,Hartley L,Ibrahim M, et al. Identification,cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human［J］. Dev Dyn, 2004, 230(1): 187198.
［6］Stojkovic M, Lako M, Stojkovic P, et al. Derivation of human embryonic stem cells from day8 blastocysts recovered after threestep in vitro culture［J］. Stem Cells, 2004, 22(5): 790797.
［7］Yu J, Vodyanik MA, SmugaOtto K, et al. Induced pluripotent stem cell lines derived from human somatic cells［J］. Science, 2007, 318(5858): 19171920.
［8］Silva J, Nichols J, Theunissen TW, et al. Nanog is the gateway to the pluripotent ground state［J］. Cell, 2009, 138(4): 722737.
［9］Hart AH, Hartley L, Parker K, et al. The pluripotency homeobox gene NANOG is expressed in human germ cell tumors［J］. Cancer, 2005, 104(10): 20922098.
［10］HoeiHansen CE, Sehested A, Juhler M, et al. New evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of pluripotency and cell differentiation markers［J］. J Pathol, 2006, 209(1): 2533.
［11］Santagata S, Ligon KL, Hornick JL. Embryonic stem cell transcription factor signatures in the diagnosis of primary and metastatic germ cell tumors［J］. Am J Surg Pathol, 2007, 31(6): 836845.
［12］You JS, Kang JK, Seo DW, et al. Depletion of embryonic stem cell signature by histone deacetylase inhibitor in NCCIT cells: involvement of Nanog suppression［J］. Cancer Res, 2009, 69(14): 57165725.
［13］Busch C, Oppitz M, Wehrmann M, et al. Immunohistochemical localization of nanog and Oct4 in stem cell compartments of human sacrococcygeal teratomas［J］. Histopathology, 2008, 52(6): 717730.
［14］Busch C, Bareiss PM, Sinnberg T, et al. Isolation of three stem cell lines from human sacrococcygeal teratomas［J］. J Pathol,2009,217(4): 589596.
［15］Siu MK, Wong ES, Chan HY, et al. Overexpression of NANOG in gestational trophoblastic diseases: effect on apoptosis, cell invasion, and clinical outcome［J］. Am J Pathol, 2008, 173(4): 11651172.
［16］BenPorath I, Thomson MW, Carey VJ, et al. An embryonic stem celllike gene expression signature in poorly differentiated aggressive human tumors［J］. Nat Genet, 2008, 40(5): 499507.
［17］Ezeh UI, Turek PJ, Reijo RA, et al. Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma［J］. Cancer, 2005, 104(10): 22552265.
［18］Nirasawa S, Kobayashi D, Tsuji N, et al. Diagnostic relevance of overexpressed Nanog gene in early lung cancers［J］. Oncol Rep, 2009, 22(3): 587591.
［19］Zhang J, Wang X, Li M, et al. NANOGP8 is a retrogene expressed in cancers［J］. FEBS J, 2006, 273(8): 17231730.
［20］陈忠，许文荣，钱晖，等.干细胞标志物Nanog的检测在胃癌诊断中的意义［J］. 临床检验杂志,2009,27(1):68.
CHEN Zhong,XU Wenrong,QIAN Hui,et al．Detection of stem cell marker Nanog and diagnostic significance for human gastric cancer［J］. Chinese Journal of Clinical Laboratory Science,2009,27(1):68.
［21］Fujii H, Honoki K, Tsujiuchi T, et al. Sphereforming stemlike cell populations with drug resistance in human sarcoma cell lines［J］. Int J Oncol, 2009, 34(5): 13811386.
［22］Wang L, Park P, Lin CY. Characterization of stem cell attributes in human osteosarcoma cell lines［J］. Cancer Biol Ther, 2009, 8(6): 543552.
［23］Singh S, Clark I，Teraski M，et al.Identification of a cancer stem cell in human brain tumors［J］.Cancer Res，2004，63(18)：582l5828.
［24］牛朝诗，倪永丰， 陈建民. 胶质母细胞瘤肿瘤干细胞的分离培养与生物学特性研究［J］. 中国微侵袭神经外科杂志，2009，14（1）：2528.
NIU Chaoshi, NI Yongfeng, CHEN Jianmin. Isolation, culture and biological characteristics of tumor stem cells in human brain glioblastoma［J］. Chinese Journal of Minimally Invasive Neurosurgery，2009，14（1）：2528.
［25］Collins AT，Berry PA，Hyde C，et al.Progpective identification of tumorigenic prostate stem cells［J］. Cancer Res，2005，65(23)：1094610951.
［26］Takaishi S,Okumura T,Wang TC. Gastric cancer stem cells［J］. J Clin Oncol, 2008, 26 (17) : 28762882.
［27］Gibbs CP, Kukekov VG, Reith JD, et al. Stemlike cells in bone sarcomas: implications for tumorigenesis［J］. Neoplasia, 2005, 7(11): 967976.
［28］Wilson H, Huelsmeyer M, Chun R, et al. Isolation and characterisation of cancer stem cells from canine osteosarcoma［J］. Vet J, 2008, 175(1): 6975.
［29］Di Fiore R, Santulli A, Ferrante RD, et al. Identification and expansion of human osteosarcomacancerstem cells by longterm 3aminobenzamide treatment［J］. J Cell Physiol, 2009, 219(2): 301313.
［30］王卫生，唐伟. 胚胎干细胞关键因子Nanog在膀胱癌中的表达及与肿瘤干细胞的关系［J］. 重庆医科大学学报，2009，34（4）：409412.
WANG Weisheng,TANG Wei. Expression of embryonic stem cells key transcription factor Nanog in bladder cancer and its relationship with cancer stem cells［J］. Journal of Chongqing Medical Universitiy,2009,34(4):409412. |
