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国际病理科学与临床杂志 2010, 30(1) 53- DOI: 10.3969/j.issn.16732588.2010. ISSN: 1673-2588 CN: 43-1458/R

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miRNA与肿瘤的研究进展

唐仪综述苏琦审校

南华大学肿瘤研究所，湖南衡阳 421001

摘要：微小RNA(microRNA, miRNA)是一种长度约为22 nt的非编码RNA，它们通过miRNA介导的特异性的基因沉默导致靶mRNA降解及抑制蛋白质的合成调控转录后基因表达水平。miRNA对细胞的增殖、分化和凋亡有重要的调节作用，在正常组织和肿瘤组织中的表达显著不同，参与了肿瘤的发生、发展。本文主要讨论miRNA在肿瘤方面的研究进展。

关键词：微小RNA 癌表达调控

Advance in the research on miRNA and tumor

TANG Yi, SU Qi

Cancer Research Institute, University of South China, Hengyang Hunan 421001, China

Abstract: MicroRNAs (miRNA) are a class of ～22nucleotides noncoding RNAs, which participate in regulating gene expression at the posttranscriptional level. Posttranscriptional silencing of target genes by miRNA occurs either by targeting specific cleavage of mRNA or by targeting specific protein synthesis. There are significantly differential expressions of miRNAs between normal tissues and cancers， suggesting that miRNAs may participate in cancer development and progression. In this review，we will discuss the progress in the study on microRNA in cancer.

Keywords: microRNA;cancer;expression regulation

收稿日期 2009-12-03 修回日期 2010-01-20 网络版发布日期

DOI: 10.3969/j.issn.16732588.2010.

基金项目:

通讯作者: 苏琦

作者简介:

作者Email: suqi1945@yahoo.com.cn

参考文献：

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