国际病理科学与临床杂志 2010, 30(1) 48- DOI:   10.3969/j.issn.16732588.2010.  ISSN: 1673-2588 CN: 43-1458/R

本期目录 | 下期目录 | 过刊浏览 | 高级检索                                                            [打印本页]   [关闭]
综述
扩展功能
本文信息
Supporting info
PDF(909KB)
[HTML全文]
参考文献[PDF]
参考文献
服务与反馈
把本文推荐给朋友
加入我的书架
加入引用管理器
引用本文
Email Alert
文章反馈
浏览反馈信息
本文关键词相关文章
脂筏
高血压发病机制
caveolae
本文作者相关文章
PubMed
脂筏在高血压发病机制中的作用
龚艳综述何芳审校
新疆石河子大学医学院病理生理教研室/新疆地方与民族高发病教育部重点实验室,新疆 石河子 832002
摘要: 原发性高血压的发病机制尚未完全明确,随着脂筏结构与功能的不断阐明,它与高血压之间的关系越来越密切。脂筏与细胞的许多重要功能有关,高血压的多种信号转导事件的发生是通过定位于脂筏及caveolae的细胞膜受体,所以脂筏在高血压的发生发展过程中起了重要的调控作用。与高血压发病机制相关的因素,如内皮型一氧化氮合成酶、细胞外钙受体、NADPH氧化酶、Rho激酶、胰岛素受体、Ca2+以及转化生长因子和丝裂原蛋白激酶信号转导通路等,这些蛋白和信号分子都定位于脂筏或者受脂筏调控,从而为脂筏与高血压发病机制之间的关系提供了更加充分的证据。本文将对各相关蛋白和信号转导与高血压的形成原因作一综述。
关键词 脂筏   高血压发病机制   caveolae  
Effect of lipid raft on the pathogenesis of hypertension
GONG Yan, HE Fang
Department of Pathophysiology, Medical College of Shihezi University/Ministry of Education Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi Xinjiang 832002, China
Abstract: The pathogenesis of essential hypertension has not fully elucidated yet. However, with the clarification of the structure and function of lipid raft (LR), its seems like there is a close relation between LR and hypertension. LR is related to many important cell functions. Multiple signal transduction pathway in hypertension are mediated by the receptors located in LR or caveolae. So LR plays an important regulatory role in the genesis and development of hypertension. The proteins and signal molecules related to the pathogenesis of hypertension, such as eNOS, CaR, NADPH oxidase, Pho kinase, InsR, Ca2+, and signal pathways of TGFβ and MAPK, are either located in LR or regulated by LR. It provides strong evidences to support the relationship between LR and the pathogenesis of hypertension. This paper summarizes the reports on the role of the abovementioned proteins and signal pathways in the pathogenesis of essential hypertension.
Keywords: lipid raft;pathogenesis of hypertension;caveolae  
收稿日期 2009-12-13 修回日期 2010-01-19 网络版发布日期  
DOI: 10.3969/j.issn.16732588.2010.
基金项目:

通讯作者: 何芳
作者简介:
作者Email: fangf2002shz@126.com

参考文献:
[1]Williams TM,Lisanti MP. Protein family review: The caveolin proteins[J]. Genome Biol, 2004, 5(3): 214. [2]Patra SK,Bettuzzi S.Epigenetic DNAmethylation regulation of genes coding for lipid raftassociated components: A role for raft proteins in cell trans formation and cancer progression(Review)[J]. Oncol Reports, 2007, 17(6): 12791290. [3]Zajchowski LD,Robbins SM. Lipid rafts and little caves.Compartmentalized signalling in membrane microdomains[J].Eur J Biochem,2002,269(3):737752. [4]Mukherjee S,Maxfield FR.Role of membrane organization and membrane domains in endocytic lipid trafficking[J].Trafic,2000,1(3):203211. [5]Clarke CJ, Forman S. Phospholipase Cδ1 modulates sus tained contraction of rat mesenteric small arteries in response to noradrenaline, but not endothelin1[J]. Am J Physiol Heart Circ Physiol,2008,295(2):826834. [6]Doherty GJ, McMahon HT. Mechanisms of endocytosis[J]. Annu Rev Biochem, 2009, 78: 857902. [7]Liu XQ, Thangavel M. Adenylyl cyclase Type 6 overexpression selectively enhances βadrenergic and prostacyclin receptormediated inhibition of cardiac fibroblast function because of colocalization in lipid rafts[J]. NaunynSchmiedebergs Arch Pharmacol, 2008, 377(46): 359369. [8]Sessa WC. Regulation of endothelial derived nitric oxide in health and disease[J]. Mem Inst Oswaldo Cruz Rio de Janeiro, 2005, 100(Suppl 1): 1518. [9]Gratton JP, Fontana J. Reconstitution of an endothelial nitricoxide synthase (eNOS), hsp90, and caveolin1 complex in Vitro[J]. J Biol Chem, 2000, 275(29):2226822272. [10]Dudzinski DM, Michel T. Life history of eNOS: Partners and path ways[J]. Cardiovasc Res, 2007,75(2): 247260. [11]Razani B, Engelman JA, Wang XB, et al. Caveolin1 nullmice are viable, but show evidence of hyperproliferative an d vascular abnormalities[J]. J Biol Chem, 2001, 276(41): 3812138138. [12]Jung SY, Kwak JO, Kim HW, et al. Calcium sensing receptor forms complex with and is upregulated by caveolin1 in cultured human osteosarcoma(Saos2) cells [J]. Exp Mol Med, 2005, 37(2): 91100. [13]TfeltHansen J, Hansen JL, Smajilovic S, et al. Calcium receptor is functionally expressed in rat neonatal ventricular cardiomyocytes[J]. Am J Physiol Heart Circ Physiol, 2006, 290(3): 11651171. [14]Smajilovic S, Hansen JL, Christoffersen TE, et al. Extracellar calcium sensing in rat atrtic vascular smooth muscle cells[J]. Biochem Biophys Res Commun, 2006, 348(4): 12151223. [15]Weston AH, Absi M,Ward DT, et al. Evidence in favor of a calciumsensing receptor in arterial endothelial cells: studies with calindol and Calhex 231[J]. Circ Res, 2005, 97(4): 391398. [16]Wu ZZ, Tandon R, Ziembicki J, et al. Role of ceramide in Ca2+sensing receptorinduced apoptosis[J]. J Lipid Res, 2005, 46(7): 13961404. [17]Jin S, Zhang Y, Yi F, et al. Critical role of lipid raft redox signaling platforms in endostatininduced coronary endothelial dysfunction[J]. Arterioscler Thromb Vasc Biol, 2008, 28(3): 485490. [18]Ju H,Behm DJ, Nerorkar S, et al. p38MAPK inhibitors ameliorate target organ damage in hypertension:Part1 p38 MAPK dependent endothelial dysfunction and hypertension[J]. J Pharmacol Exp Ther, 2003, 307(3): 932938. [19]Taniyama Y,UshioFukai M. Role of p38 MAPK and MAPK2 in angiotensinⅡ induced akt activation in vascular smooth muscle cells[J]. Am J Physiol, 2004, 287(2): 494499. [20]Mineo C, James GL, Smart EJ, et al. Localization of epidermal growth factor stimulated Rad/Raf interaction to caveolae membrane[J]. J Biol Chem, 1996, 271(20): 11930935. [21]Francesconi A, Kumari R, Zukin RS. Regulation of group I metabotropic glutamate receptor trafficking and signaling by the caveolar/lipid raft pathway [J]. J Neurosci, 2009, 29 (11):35903602. [22]Suthanthitan M, Li B, Song JO, et al. Transforming growth factorβ1 hyperexpression in African—American hypertensive: a novel mediator of hypertension and/or target organ damage[J].Proc Natl Acad Sci USA, 2000, 97(7): 34793484. [23]Schwartz EA, Reaven E. Transforming growth factorβ receptors localize to caveolae and regulate endothelial nitric oxide synthase in normal human endothelial cells[J]. Biochem J, 2005, 390(Pt 1): 199206. [24]Han WX, Li HW, Villar VA, et al.Lipid rafts keep NADPH oxidase in the inactive state in human renal proximal tubule cells[J].Hypertension, 2008, 51(2): 481487. [25]UshioFukai M, Zuo L, Ikeda S, et al. cAb1 tyrosine kinase mediates reactive oxygen species and caveolindependent AT1 receptor signaling in vascular smooth muscle: role in vascular hypertrophy[J]. Circ Res, 2005, 97(8): 829836. [26]Chalupsky K, Cai H. Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensinⅡ uncoupling of endothelial nitric oxide synthase[J]. Proc Natl Acad Sci USA, 2005, 102(25): 90569061. [27]Wilcox CS. Oxidative stress and nitric oxide deficiency in the kidney: a critical link to hypertension?[J]. Am J Physiol Regul Integr Comp Physiol, 2005, 289(4): R913R935. [28]Salanueva IJ, Cerezo A, Guadamillas MC, et al. Integrin regulation of caveolin function[J]. Cell Mol Med, 2007, 11(5): 969980. [29]Higashi M, Mukai Y, Matoba T, et al. Longterm inhibition of Rhokinase suppresses angiotensin Ⅱinduced formation of coronary vascular lesions and cardiac hypertrophy in rats in vivo[J].Cireulation, 2001, 104(suppl II): 325. [30]Tsujikawa H, Song YM, Watanabe M, et al. Cholesterol depletion modulates basal Ltype Ca2+ current and abolishes its βadrenergic enhancement in ventricular myocytes[J]. Am J Physiol Heart Circ Physiol, 2008, 294(1): 285292. [31]Kikuchi T, Oka N, Koga A, et al. Behavior of caveolae and ceaveolin3 during the development of myoeyte hypertrophy[J].J Cardiovasc Pharmacol, 2005, 45(3): 204210. [32]Yamamoto M, Toya Y, Schwencke C, et al. Caveolin is an activator of insulin receptor signaling[J]. J Biol Chem, 1998, 273(41): 2696226968. [33]Katagiri H, Yamada T, Oka Y. Adiposity and cardiovascular disorders: Disturbance of the regulatory system consisting of humoral and neuronal signais[J].Circ Res, 2007, 101(1):2739. [34]Strazzullo P,Barbato A,Galletti F, et al.Abnormalities of renal sodium handling in the metabolic syndrome: Results of the olivetti heart study[J].J Hypertens, 2006, 24 (8):16331639.
本刊中的类似文章
1.杜新,赖学莉;黄颂敏.脂筏蛋白与Cb1相关蛋白在葡萄糖转运中的信号转导机制[J]. 国际病理科学与临床杂志, 2006,26(2): 12-138

Copyright by 国际病理科学与临床杂志