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国际病理科学与临床杂志 2010, 30(1) 39- DOI:
10.3969/j.issn.16732588.2010. ISSN: 1673-2588 CN: 43-1458/R |
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| 论著 |
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DNAJB6蛋白在乳腺癌中的表达及临床意义 |
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陈勇武1， 王川2， 傅芳萌2， 许国玺1， 杨发端3， 康德勇3 |
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福建医科大学1.附属协和临床医学院肿瘤科， 福州 350004； 2.附属协和医院肿瘤科，
福州 350004； 3.附属协和医院病理科，福州 350004 |
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摘要：
目的：探讨DNAJB6蛋白在乳腺癌中的表达及临床意义。方法：采用免疫组织化学的方法检测78例乳腺癌组织DNAJB6蛋白水平的表达，分析其与临床病理特征的关系。结果：DNAJB6蛋白低表达率为62.8% (49/78)，DNAJB6蛋白的表达水平与乳腺肿瘤大小、组织学分级负相关(分别为rs=-0.254和rs=-0.293，P＜0.05)。结论：DNAJB6蛋白低表达与乳腺癌恶性程度有关。 |
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关键词：
乳腺癌
DNAJB6蛋白
免疫组织化学
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Protein expression of DNAJB6 and its
clinical significance in breast cancer |
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CHEN Yongwu1, WANG Chuan2, FU Fangmeng2, XU Guoxi1, YANG Faduan3, KANG Deyong3 |
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1. Department of Oncology, Clinical Academy of Fujian Medical University Union Hospital，Fuzhou 350004;
2. Department of Oncology, Fujian Medical University Union Hospital，Fuzhou 350004; 3. Department of
Pathology, Fujian Medical University Union Hospital，Fuzhou 350004，China |
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Abstract:
Objective To investigate the protein expression of DNAJB6 and its clinical significance in breast cancer. MethodsImmunohistochemical staining was performed to detect the expression of DNAJB6 protein in 78 specimens of breast cancer, and the correlation between the expression of DNAJB6 protein and the clinicopathologic characteristics was analyzed.ResultsAmong 78 samples 49(62.8%) were at low expression level of DNAJB6 protein. The expression level of DNAJB6 protein was negatively correlated with the size of the tumor and histological grade in breast cancer (rs=-0.254 and rs=-0.293 respectively，P＜0.05). Conclusion The low expression level of DNAJB6 protein is associated with the malignant biological characteristics of breast cancer. |
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Keywords:
breast neoplasms;DNAJB6 protein;immunohistochemistry
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收稿日期 2009-11-04 修回日期 2010-01-08 网络版发布日期 |
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DOI: 10.3969/j.issn.16732588.2010. |
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基金项目:
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通讯作者: 王川 |
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作者简介: |
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作者Email: chuanwang1968@hotmail.com |
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| 参考文献： |
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