国际病理科学与临床杂志 2010, 30(1) 20- DOI:   10.3969/j.issn.16732588.2010.  ISSN: 1673-2588 CN: 43-1458/R
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乳腺
导管病变
增生性病变
p63
CK5/6
本文作者相关文章
PubMed
乳腺导管不同类型增生性病变中p63和 CK5/6的表达及意义
梁鑫1， 黄受方2， 周小鸽2
首都医科大学1.附属北京妇产医院 病理科， 北京 100006； 2.附属友谊医院 病理科， 北京 100050
摘要： 目的：明确不同类型的乳腺导管增生性病变中p63和Cytokeratin 5/6(CK5/6)的表达和意义。方法：对150例乳腺导管增生性病变中的368个病灶分别进行p63和CK5/6染色。结果：CK5/6在正常乳腺组织中的肌上皮和导管上皮均阳性表达，35例普通型增生中，33例CK5/6呈马赛克式阳性表达，仅2例弥漫阳性；在非典型性增生、原位癌和浸润癌中，CK5/6主要呈阴性表达，仅6例阳性，其中有2例雌激素受体（estrogen receptor, ER）、孕激素受体（progesterone receptor, PR）和CerbB2阴性，符合基底细胞样癌的特点。p63在良性病变和非浸润性肿瘤性增生病变中的肌上皮细胞阳性表达，3例原位癌不表达p63和CK5/6。浸润癌中有3例（3/43）p63散在肿瘤细胞阳性，其余均阴性。结论：不同类型乳腺增生性病变中p63及CK5/6的染色模式存在一定规律，有助于这些病变的诊断和鉴别诊断。
关键词： 乳腺   导管病变   增生性病变   p63   CK5/6  
Expression of p63 and CK5/6 in different breast intraductal proliferative lesions and its significance in the diagnosis
LIANG Xin1， HUANG Shoufang2， ZHOU Xiaoge2
1.Department of Pathology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University,　Beijing 100006; 2.Department of Pathology, Beijing Friendship Hospital, Capital Medical University,　Beijing 100050，China
Abstract: Objective To determine the expression of p63 and CK5/6 in different breast intraductal proliferative lesions and its significance in the diagnosis.MethodsThe expression of p63 and CK5/6 in 368 breast lesions from 150 samples was analyzed by immunohistochemical staining.ResultsIn the normal breast tissues, the expression of CK5/6 existed in myoepithelial and luminal epithelial cells. Among the 35 general proliferative lesions, 33 of CK5/6 staining showed mosaic pattern and 2 displayed diffuse positive pattern. In the atypical proliferative lesions, insitu carcinoma, or infiltrating ductal carcinoma, the expression of CK5/6 was all negative except 6 cases. Among the 6 positive cases, 2 were negative in the expression for estrogen receptor (ER), progesterone receptor (PR), and CerbB2, which were consistent with the characters of basaloid carcinoma. The expression of p63 existed in benign and noninfiltrated malignant lesions, whereas the expressions of p63 and CK5/6 were negative in 3 cases of insitu carcinoma. In the infiltrated carcinoma, the expression of p63 was only seen in 3 cases（3/43）.Conclusion The staining patterns of p63 and CK5/6 display special features in different breast intraductal proliferative lesions, which are benefit to the diagnosis and differential diagnose of various hyperplasia lesions.
Keywords: breast;ductal lesion;hyperplasia lesion;p63;ck5/6  
收稿日期 2009-11-13 修回日期 2009-12-30 网络版发布日期  
DOI: 10.3969/j.issn.16732588.2010.
基金项目:

通讯作者: 周小鸽
作者简介:
作者Email: arhus@ccp.net.cn
参考文献：
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