国际病理科学与临床杂志 2009, 29(6) 532-536 DOI:     ISSN: 1673-2588 CN: 43-1458/R

本期目录 | 下期目录 | 过刊浏览 | 高级检索                                                            [打印本页]   [关闭]
综述
扩展功能
本文信息
Supporting info
PDF(1020KB)
[HTML全文]
参考文献[PDF]
参考文献
服务与反馈
把本文推荐给朋友
加入我的书架
加入引用管理器
引用本文
Email Alert
文章反馈
浏览反馈信息
本文关键词相关文章
胰高血糖素样肽-1
胰岛&beta
细胞
糖尿病
本文作者相关文章
PubMed
胰高血糖素样肽-1对胰岛β细胞的影响
孙琴综述,任安审校
安徽医科大学附属省立医院内分泌科, 合肥 230001
摘要

 胰高血糖素样肽-1,作为一种“肠促胰素”,对胰岛β细胞具有多方面积极的影响。它可刺

激胰岛β细胞分泌胰岛素,促进它的增殖分化再生并抑制其凋亡,在糖尿病的治疗中有很好的应用前景

关键词 胰高血糖素样肽-1   胰岛&beta   细胞   糖尿病  
Effect of glucagon-like peptide-1 on pancreatic β-cells
SUN Qin, REN An
Department of Endocrinology, Affiliated Anhui Provincial Hospital of Anhui Medical University,Hefei 230001,China
Abstract:

Glucagon-like peptide-1,as one of “incretins”,is beneficial to pancreatic

β-cells. It can enhance insulin secretion, proliferation ,differiention ,regeneration 

and inhibit the apoptosis of pancreatic β-cells. So it has promising prospects for

diabetes mellitus treatment.

Keywords: glucagon-like peptide-1;pancreatic β-cells;diabetes  
收稿日期 2009-09-03 修回日期 2009-10-13 网络版发布日期  
DOI:
基金项目:

通讯作者: 任安
作者简介:
作者Email: ren_an@163.com

参考文献:

[1]Dupre J, Ross SA, Watson D,et al. Stimulation of insulin secretion by gastric

inhibitory polypeptide in man [J].J Clin Endocrinol Metab,1973,37(5):826-828.
[2]Edholm T, Cejvan K, Abdel-Halim SM,et al.The incretin hormones GIP and GLP-1 in

diabetic rats: effects on insulin secretion and small bowel motility [J].

Neurogastroenterol Motil, 2009,21(3):313-321.
[3]Vilsbll T, Brock B, Perrild H,et al.Liraglutide, a once-daily human GLP-1

analogue, improves pancreatic B-cell function and arginine-stimulated insulin secretion

during hyperglycaemia in patients with Type 2 diabetes mellitus [J]. Diabet Med,2008,25

(2):152-156.
[4]Behme MT, Dupré J, McDonald TJ. Glucagon-like peptide 1 improved glycemic control in

Type 1 diabetes [J].BMC Endocr Disord,2003,3(1):3.
[5]Kendall DM,Riddle MC,Rosenstock J,et al.Effects of exenatide(exendin4) on glycemic

control over 30 weeks in patients with Type 2 diabetes treated with metformin and a

sulfonylurea[J]. Diabetes Care,2005,28(5):1083-1091.
[6]Gromada J, Ding WG, Barg S, et al. Multisite regulation of insulin secretion by

cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via

distinct receptors [J].Pflugers Arch,1997,434(5):515-524.
[7]Lin YF, Jan YN, Jan LY. Regulation of ATP-sensitive potassium channel function by

protein kinase A-mediated phosphorylation in transfected HEK293 cells [J].EMBO J,2000,19

(5):942-955.
 [8]MacDonald PE, El-Kholy W, Riedel MJ,et al.The multiple actions of GLP-1 on the

process of glucose-stimulated insulin secretion [J].Diabetes,2002,51(3):S434-S442.
[9]Holz GG. New insights concerning the glucose-dependent insulin secretagogue action of

glucagon-like peptide-1 in pancreatic beta-cells[J].Horm Metab Res,2004,36(11-12):787-

794.
[10]Shigeto M, Katsura M, Matsuda M, et al. Low, but physiological, concentration of

GLP-1 stimulates insulin secretion independent of the cAMP-dependent protein kinase

pathway[J].J Pharmacol Sci, 2008,108(3):274-279.
[11]Garber A, Henry R, Ratner R,et al. Liraglutide versus glimepiride monotherapy for

Type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-

treatment trial [J].Lancet,2009,373(9662):438-439.
[12] Mauricio D, Mandrup-Poulsen T.Apoptosis and the pathogenesis of IDDM:a question of

life and death [J].Diabetes,1998,47(10):1537-1543.
 [13] Maedler K, Spinas GA, Dyntar D,et al.Distinct effects of saturated and

monounsaturated fatty acids on β-cell turnover and function[J].Diabetes,2001,50(1):69-

76.
[14] Bregenholt S, Mldrup A, Blume N,et al.The long-acting glucagon-like peptide-1

analogue,liraglutide,inhibits β-cell apoptosis in vitro[J].Biochem Biophys Res Commun,

2005,330(2):577-584.
[15] Li Y, Hansotia T,Yusta B,et al.Glucagon-like peptide-1 receptor signaling modulates

β-cell apoptosis[J].J Biol Chem, 2003,278(1):471-478.
[16]Li L, El-Kholy W, Rhodes CJ, et al.Glucagon-like peptide-1 protects beta cells from

cytokine-induced apoptosis and necrosis: role of protein kinase B

[J].Diabetologia,2005,48(7):1339-1349.
[17]Ferdaoussi M, Abdelli S, Yang JY,et al. Exendin-4 protects beta-cells from

interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase

pathway[J].Diabetes, 2008,57(5):1205-1215.
 [18]刘礼斌,王燕萍,潘晓东,等.Exendin-4体外通过抑制NF-Kapppa B-iNOS-NO信号心减轻氧化诱

导的小鼠MIN6胰岛β细胞凋亡[J].药学学报,2008,43(7):690-694.
LIU Libin,WANG Yanping,PAN Xiaodong,et al.Exendin-4 protected murine MIN6 pancreatic

beta-cells from exidative stress-induced apoptosis via down-regulation of NF-Kapppa B-

iNos-No pathway[J].Acta Pharmaceutical Sinica, 2008,43(7):690-694.
[19]Farilla L, Bulotta A, Hirshberg B,et al.Glucagon-like peptide 1 inhibits cell

apoptosis and improves glucose responsiveness of freshly isolated human islets

[J].Endocrinology, 2003,144(12):5149-5158.
[20]Tews D, Werner U, Eckel J. Enhanced protection against cytokine- and fatty acid-

induced apoptosis in pancreatic beta cells by combined treatment with glucagon-like

peptide-1 receptor agonists and insulin analogues [J].Horm Metab Res,2008,40(3):172-180.
[21] Stoffers DA, Kieffer TJ, Hussain MA,et al.Insulinotropic glucagon-like peptide 1

agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in

mouse pancreas [J].Diabetes,2000,49(5):741-748.
[22]Jonsson J, Carlsson L, Edlund T, et al.Insulin-promoter  factor 1 is required for

pancreas development in mice [J].Nature,1994,371(6498):606-609.
 [23]Hui H, Perfetti R. Pancreas duodenum homeobox-1 regulates pancreas development

during embryogenesis and islet cell function in adulthood [J].Eur J Endocrinol,2002,146

(2):129-141.
[24]Stoffers DA, Ferrer J, Clarke WL, et al. Early-onset type-II diabetes mellitus

(MODY4) linked to IPF1 [J]. Nat Genet,1997,17(2):138-139.
[25]Feanny MA, Fagan SP, Ballian N,et al.PDX-1 expression is associated with islet

proliferation in vitro and in vivo [J].J Surg Res,2008,144(1):8-16.
 [26]Movassat J, Beattie GM, Lopez AD, et al. Exendin 4 up-regulates expression of PDX 1

and hastens differentiation and maturation of human fetal pancreatic cells [J].J Clin

Endocrinol Metab,2002,87(10):4775-4781.
[27]Li L, Lili R, Hui Q,et al. Combination of GLP-1 and sodium butyrate promote

differentiation of pancreatic progenitor cells into insulin-producing cells [J].Tissue

Cell,2008,40(6):437-445.
[28]Kang HM, Kim J, Park S,et al.Insulin-secreting cells from human eyelid-derived stem

cells alleviate Type I diabetes in immunocompetent mice[J].Stem Cells,2009,27(8):1999-

2008.
[29]Zhang J, Tokui Y, Yamagata K, et al.Continuous stimulation of human glucagon-like

peptide-1 (7-36) amide in a mouse model (NOD) delays onset of autoimmune Type 1 diabetes[

J].Diabetologia, 2007,50(9):1900-1909.
[30]Tourrel C, Bailbe D, Meile MJ, et al. Glucagon-like peptide-1 and exendin-4

stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in

persistently improved glucose homeostasis at adult age[J].Diabetes,2001,50(7): 1562-

1570.
[31]Tourrel C, Bailbe D, Lacorne M, et al.Persistent improvement of Type 2 diabetes in

the Goto-Kakizaki rat model by expansion of the β-cell mass during the prediabetic period

with glucagon-like peptide-1 or exendin-4 [J].Diabetes,2002, 51(5):1443-1452.
[32]Susini S, Roche E, Prentki M, et al. Glucose and glucoincretin peptides synergize to

induce c-fos, c-jun, junB, zif-268, and nur-77 gene expression in pancreatic beta(INS-1)

cells [J].FASEB J,1998,12(12):1173-1182.
[33]Buteau J, Roduit R, Susini S, et al. Glucagon-like peptide-1 promotes DNA synthesis,

activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and

duodenal homeobox gene 1 (PDX-1) DNA binding activity in (INS-1) β- cells

[J].Diabetologia,1999,42(7):856-864.
[34]Wang Q,Li L,Xu E,et al. Glucagon-like peptide-1 regulates proliferation and

apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells

[J].Diabetologia,2004,47(3):478-487.
[35]Buteau J, Foisy S, Joly E,et al.Glucagon-like peptide 1 induces pancreatic beta-cell

proliferation via transactivation of the epidermal growth factor receptor[J].Diabetes,

2003,52(1):124-132.
[36]Liu Z, Habener JF. Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt

signaling enhances pancreatic beta cell proliferation [J].J Biol Chem,2008,283(13):8723

-8735.
[37]Shu L, Matveyenko AV, Kerr-Conte J,et al.Decreased TCF7L2 protein levels in Type 2

diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired

beta-cell function.[J].Hum Mol Genet, 2009,18(13):2388-2399.

本刊中的类似文章
1.欧阳果良,陈彦,易红,冯雪萍,张鹏飞,李茂玉,李萃,阮林,彭芳,陈主初,肖志强.Raf激酶抑制蛋白对鼻咽癌细胞增殖的影响[J]. 国际病理科学与临床杂志, 2008,28(1): 1-5
2.李爱玲;修瑞娟 .微循环, 纳米医学的研究平台[J]. 国际病理科学与临床杂志, 2008,28(3): 19-276
3.孙致连;叶山东 .炎症因子与糖尿病肾病关系的研究进展[J]. 国际病理科学与临床杂志, 2008,28(4): 20-369
4.唐春莲;姚根有.胃癌伴神经内分泌分化的研究进展[J]. 国际病理科学与临床杂志, 2007,27(2): 9-132
5.赵婧;董文斌.细胞凋亡的线粒体途径与缺血缺氧性肾损伤[J]. 国际病理科学与临床杂志, 2007,27(6): 17-544
6.董源媛综述 肖新华 审校.脂联素对糖尿病大血管病变的影响[J]. 国际病理科学与临床杂志, 2008,28(5): 19-455
7.雷亚丽综述 李代强 审校.非小细胞肺癌表皮生长因子受体及其靶向治疗研究进展[J]. 国际病理科学与临床杂志, 2009,29(1): 59-63
8.陈茜1,刘亚伟2,黄邵2 ,杨勤1 综述 姜勇2审校.细胞穿透肽穿膜机制的研究进展[J]. 国际病理科学与临床杂志, 2009,29(2): 115-120
9.冷小飞综述 万小云,陈小君审校.肿瘤干细胞与卵巢癌[J]. 国际病理科学与临床杂志, 2009,29(2): 144-147
10.张春梅1综述 李春艳2, 崔泽实2审校.Wnt和Notch信号通路在肿瘤干细胞自我更新中的作用[J]. 国际病理科学与临床杂志, 2008,28(6): 4-481
11.褚永权1综述 叶再元1, 赵仲生2 审校.SPARC与消化道肿瘤的浸润转移
[J]. 国际病理科学与临床杂志, 2008,28(6): 5-486
12.王秋艳1,杜文娟2, 李继科3,杨艳波4, 于波2 .小鼠Wnt-1基因真核表达载体构建及其在大鼠成肌细胞中的表达[J]. 国际病理科学与临床杂志, 2009,29(3): 196-201
13.韦怡怡综述 罗军, 卢玉英审校.NPM1基因突变与急性髓细胞白血病[J]. 国际病理科学与临床杂志, 2008,28(6): 7-495
14.董家龙综述 李菊香, 洪葵审校.Rho相关激酶Rock在心血管疾病中的研究进展[J]. 国际病理科学与临床杂志, 2009,29(3): 263-266
15.张丹综述 王海杰审校.缺血缺氧状态下细胞自噬的研究进展[J]. 国际病理科学与临床杂志, 2009,29(4): 293-297

Copyright by 国际病理科学与临床杂志