| 国际病理科学与临床杂志 2009, 29(6) 532-536 DOI: ISSN: 1673-2588 CN: 43-1458/R | |||||||||||||||||||||||||||||||||||||||||||
| 本期目录 | 下期目录 | 过刊浏览 | 高级检索 [打印本页] [关闭] | |||||||||||||||||||||||||||||||||||||||||||
| 综述 |
| ||||||||||||||||||||||||||||||||||||||||||
| 胰高血糖素样肽-1对胰岛β细胞的影响 | |||||||||||||||||||||||||||||||||||||||||||
| 孙琴综述,任安审校 | |||||||||||||||||||||||||||||||||||||||||||
| 安徽医科大学附属省立医院内分泌科, 合肥 230001 | |||||||||||||||||||||||||||||||||||||||||||
| 摘要:
胰高血糖素样肽-1,作为一种“肠促胰素”,对胰岛β细胞具有多方面积极的影响。它可刺 激胰岛β细胞分泌胰岛素,促进它的增殖分化再生并抑制其凋亡,在糖尿病的治疗中有很好的应用前景 。 | |||||||||||||||||||||||||||||||||||||||||||
| 关键词: 胰高血糖素样肽-1 胰岛&beta 细胞 糖尿病 | |||||||||||||||||||||||||||||||||||||||||||
| Effect of glucagon-like peptide-1 on pancreatic β-cells | |||||||||||||||||||||||||||||||||||||||||||
| SUN Qin, REN An | |||||||||||||||||||||||||||||||||||||||||||
| Department of Endocrinology, Affiliated Anhui Provincial Hospital of Anhui Medical University,Hefei 230001,China | |||||||||||||||||||||||||||||||||||||||||||
| Abstract:
Glucagon-like peptide-1,as one of “incretins”,is beneficial to pancreatic β-cells. It can enhance insulin secretion, proliferation ,differiention ,regeneration and inhibit the apoptosis of pancreatic β-cells. So it has promising prospects for diabetes mellitus treatment. | |||||||||||||||||||||||||||||||||||||||||||
| Keywords: glucagon-like peptide-1;pancreatic β-cells;diabetes | |||||||||||||||||||||||||||||||||||||||||||
| 收稿日期 2009-09-03 修回日期 2009-10-13 网络版发布日期 | |||||||||||||||||||||||||||||||||||||||||||
| DOI: | |||||||||||||||||||||||||||||||||||||||||||
| 基金项目: | |||||||||||||||||||||||||||||||||||||||||||
| 通讯作者: 任安 | |||||||||||||||||||||||||||||||||||||||||||
| 作者简介: | |||||||||||||||||||||||||||||||||||||||||||
| 作者Email: ren_an@163.com | |||||||||||||||||||||||||||||||||||||||||||
|
| |||||||||||||||||||||||||||||||||||||||||||
| 参考文献: | |||||||||||||||||||||||||||||||||||||||||||
[1]Dupre J, Ross SA, Watson D,et al. Stimulation of insulin secretion by gastric inhibitory polypeptide in man [J].J Clin Endocrinol Metab,1973,37(5):826-828. diabetic rats: effects on insulin secretion and small bowel motility [J]. Neurogastroenterol Motil, 2009,21(3):313-321. analogue, improves pancreatic B-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with Type 2 diabetes mellitus [J]. Diabet Med,2008,25 (2):152-156. Type 1 diabetes [J].BMC Endocr Disord,2003,3(1):3. control over 30 weeks in patients with Type 2 diabetes treated with metformin and a sulfonylurea[J]. Diabetes Care,2005,28(5):1083-1091. cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via distinct receptors [J].Pflugers Arch,1997,434(5):515-524. protein kinase A-mediated phosphorylation in transfected HEK293 cells [J].EMBO J,2000,19 (5):942-955. process of glucose-stimulated insulin secretion [J].Diabetes,2002,51(3):S434-S442. glucagon-like peptide-1 in pancreatic beta-cells[J].Horm Metab Res,2004,36(11-12):787- 794. GLP-1 stimulates insulin secretion independent of the cAMP-dependent protein kinase pathway[J].J Pharmacol Sci, 2008,108(3):274-279. Type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel- treatment trial [J].Lancet,2009,373(9662):438-439. life and death [J].Diabetes,1998,47(10):1537-1543. monounsaturated fatty acids on β-cell turnover and function[J].Diabetes,2001,50(1):69- 76. analogue,liraglutide,inhibits β-cell apoptosis in vitro[J].Biochem Biophys Res Commun, 2005,330(2):577-584. β-cell apoptosis[J].J Biol Chem, 2003,278(1):471-478. cytokine-induced apoptosis and necrosis: role of protein kinase B [J].Diabetologia,2005,48(7):1339-1349. interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway[J].Diabetes, 2008,57(5):1205-1215. 导的小鼠MIN6胰岛β细胞凋亡[J].药学学报,2008,43(7):690-694. beta-cells from exidative stress-induced apoptosis via down-regulation of NF-Kapppa B- iNos-No pathway[J].Acta Pharmaceutical Sinica, 2008,43(7):690-694. apoptosis and improves glucose responsiveness of freshly isolated human islets [J].Endocrinology, 2003,144(12):5149-5158. induced apoptosis in pancreatic beta cells by combined treatment with glucagon-like peptide-1 receptor agonists and insulin analogues [J].Horm Metab Res,2008,40(3):172-180. agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas [J].Diabetes,2000,49(5):741-748. pancreas development in mice [J].Nature,1994,371(6498):606-609. during embryogenesis and islet cell function in adulthood [J].Eur J Endocrinol,2002,146 (2):129-141. (MODY4) linked to IPF1 [J]. Nat Genet,1997,17(2):138-139. proliferation in vitro and in vivo [J].J Surg Res,2008,144(1):8-16. and hastens differentiation and maturation of human fetal pancreatic cells [J].J Clin Endocrinol Metab,2002,87(10):4775-4781. differentiation of pancreatic progenitor cells into insulin-producing cells [J].Tissue Cell,2008,40(6):437-445. cells alleviate Type I diabetes in immunocompetent mice[J].Stem Cells,2009,27(8):1999- 2008. peptide-1 (7-36) amide in a mouse model (NOD) delays onset of autoimmune Type 1 diabetes[ J].Diabetologia, 2007,50(9):1900-1909. stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age[J].Diabetes,2001,50(7): 1562- 1570. the Goto-Kakizaki rat model by expansion of the β-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4 [J].Diabetes,2002, 51(5):1443-1452. induce c-fos, c-jun, junB, zif-268, and nur-77 gene expression in pancreatic beta(INS-1) cells [J].FASEB J,1998,12(12):1173-1182. activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in (INS-1) β- cells [J].Diabetologia,1999,42(7):856-864. apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells [J].Diabetologia,2004,47(3):478-487. proliferation via transactivation of the epidermal growth factor receptor[J].Diabetes, 2003,52(1):124-132. signaling enhances pancreatic beta cell proliferation [J].J Biol Chem,2008,283(13):8723 -8735. diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function.[J].Hum Mol Genet, 2009,18(13):2388-2399. |
|||||||||||||||||||||||||||||||||||||||||||
| 本刊中的类似文章 | |||||||||||||||||||||||||||||||||||||||||||
| 1.欧阳果良,陈彦,易红,冯雪萍,张鹏飞,李茂玉,李萃,阮林,彭芳,陈主初,肖志强.Raf激酶抑制蛋白对鼻咽癌细胞增殖的影响[J]. 国际病理科学与临床杂志, 2008,28(1): 1-5 | |||||||||||||||||||||||||||||||||||||||||||
| 2.李爱玲;修瑞娟 .微循环, 纳米医学的研究平台[J]. 国际病理科学与临床杂志, 2008,28(3): 19-276 | |||||||||||||||||||||||||||||||||||||||||||
| 3.孙致连;叶山东 .炎症因子与糖尿病肾病关系的研究进展[J]. 国际病理科学与临床杂志, 2008,28(4): 20-369 | |||||||||||||||||||||||||||||||||||||||||||
| 4.唐春莲;姚根有.胃癌伴神经内分泌分化的研究进展[J]. 国际病理科学与临床杂志, 2007,27(2): 9-132 | |||||||||||||||||||||||||||||||||||||||||||
| 5.赵婧;董文斌.细胞凋亡的线粒体途径与缺血缺氧性肾损伤[J]. 国际病理科学与临床杂志, 2007,27(6): 17-544 | |||||||||||||||||||||||||||||||||||||||||||
| 6.董源媛综述 肖新华 审校.脂联素对糖尿病大血管病变的影响[J]. 国际病理科学与临床杂志, 2008,28(5): 19-455 | |||||||||||||||||||||||||||||||||||||||||||
| 7.雷亚丽综述 李代强 审校.非小细胞肺癌表皮生长因子受体及其靶向治疗研究进展[J]. 国际病理科学与临床杂志, 2009,29(1): 59-63 | |||||||||||||||||||||||||||||||||||||||||||
| 8.陈茜1,刘亚伟2,黄邵2 ,杨勤1 综述 姜勇2审校.细胞穿透肽穿膜机制的研究进展[J]. 国际病理科学与临床杂志, 2009,29(2): 115-120 | |||||||||||||||||||||||||||||||||||||||||||
| 9.冷小飞综述 万小云,陈小君审校.肿瘤干细胞与卵巢癌[J]. 国际病理科学与临床杂志, 2009,29(2): 144-147 | |||||||||||||||||||||||||||||||||||||||||||
| 10.张春梅1综述 李春艳2, 崔泽实2审校.Wnt和Notch信号通路在肿瘤干细胞自我更新中的作用[J]. 国际病理科学与临床杂志, 2008,28(6): 4-481 | |||||||||||||||||||||||||||||||||||||||||||
| 11.褚永权1综述 叶再元1, 赵仲生2 审校.SPARC与消化道肿瘤的浸润转移 [J]. 国际病理科学与临床杂志, 2008,28(6): 5-486 |
|||||||||||||||||||||||||||||||||||||||||||
| 12.王秋艳1,杜文娟2, 李继科3,杨艳波4, 于波2 .小鼠Wnt-1基因真核表达载体构建及其在大鼠成肌细胞中的表达[J]. 国际病理科学与临床杂志, 2009,29(3): 196-201 | |||||||||||||||||||||||||||||||||||||||||||
| 13.韦怡怡综述 罗军, 卢玉英审校.NPM1基因突变与急性髓细胞白血病[J]. 国际病理科学与临床杂志, 2008,28(6): 7-495 | |||||||||||||||||||||||||||||||||||||||||||
| 14.董家龙综述 李菊香, 洪葵审校.Rho相关激酶Rock在心血管疾病中的研究进展[J]. 国际病理科学与临床杂志, 2009,29(3): 263-266 | |||||||||||||||||||||||||||||||||||||||||||
| 15.张丹综述 王海杰审校.缺血缺氧状态下细胞自噬的研究进展[J]. 国际病理科学与临床杂志, 2009,29(4): 293-297 | |||||||||||||||||||||||||||||||||||||||||||
| Copyright by 国际病理科学与临床杂志 | |||||||||||||||||||||||||||||||||||||||||||