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乳腺肿瘤 |
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组织芯片 |
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免疫组织化学 |
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基质金属蛋白酶-13 |
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| PubMed | |
乳腺癌中的表达及其临床意义
目的：探讨基质金属蛋白酶-13（matrix metalloproteinase-13， MMP-13）在乳腺癌发生、发展过程中的临床意义。方法：应用组织芯片技术和免疫组织化学SP法检测MMP-13在97例乳腺癌和39例乳腺纤维腺瘤中的表达情况，并分析其与临床病理参数的关系。结果：乳腺癌中MMP-13的表达（65.98%）显著高于乳腺纤维腺瘤（23.08%），其表达与腋窝淋巴结转移、临床分期有关，而与患者年龄、肿瘤大小无关。结论：MMP-13与乳腺癌的发生、发展有着密切关系,可作为评估乳腺癌转移和预后的重要生物学指标。
breast cancers by tissue microarray
Weifang People’s Hospital of Weifang Medical College,Weifang Shandong 261041,China
Objective To determine expression of matrix metalloproteinase-13 (MMP-13) in breast cancers and to evaluate its clinical significance.MethodsThe tissue microarray and immunohistochemistry SP methods were used to detect the MMP-13 expression in 97 cases of breast cancer and 39 cases of breast fibroadenoma and its correlation with clinicopathologic features was analyzed.ResultsThe MMP-13 expression was significantly higher in the breast cancers than that of breast fibroadenoma.In the breast cancers,MMP-13 expression was associated with axillary lymph node metastasis and TNM stage(tumor,nodes,metastasis-classification),but it was not associated with the patient age and tumor size. Conclusion There is a close relation between MMP-13 and the genesis and development of breast cancer，and MPP-13 can serve as an important index in metastasis and prognosis in breast cancer.
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［5］姜蕊，吴翠环，于世英.非小细胞肺癌中基质金属蛋白酶13和其抑制剂1表达及与预后的关系研究［J］. 中国组织化学与细胞化学杂志，2008，17（2）：132-136.
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