红细胞生成素(erythropoietin,EPO) 和红细胞生成素受体（erythropoietin receptor，EPOR）是调节红系祖细胞增殖、分化和生存所必需的关键细胞因子。近年来，国内外研究进一步发现，EPOR不仅存在于幼红细胞，在其它细胞也有发现，EPO和EPOR的作用更为广泛。本文对EPO/EPOR及其细胞内外一系列信号转导机制进行综述。

Erythropoietin (EPO) and erythropoietin receptor (EPOR) are the essential key cytokines in regulating the proliferation, differentiation and survival of erythroid progenitors. Recently, more and more studies have demonstrated that EPOR also exists in other type of cells in addition to normoblasts, suggesting that EPO and EPOR may have much more extensive biological functions. Here, we reviewed the intracellular signal transduction pathways activated by the EPO and the underlying mechanisms.

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