磁性纳米介质在医药等诸多领域有广泛的应用价值，如肿瘤磁感应热疗、影像诊断、药物载体等。而磁性介质的生物相容性是其在医学领域中应用的前提。本文主要对磁流体、磁性脂质体这类磁性纳米介质的毒理学研究进展磁性纳米介质体内、体外毒性评价实验，相关评价指标的研究进展及磁性介质毒理学研究中存在的问题进行综述。

The magnetic nano materials have been widely applied in the medical fields, such as magnetic thermotherapy for tumor, imaging diagnosis, and drug vector. The application perspective of magnetic materials in medical field is closely associated with its biocompatibility. This article mainly concentrates on the progress in the research of magnetic fluid, magnetic liposomes and the toxicology of these magnetic nano materials. In addition, the toxicity (or related index) evaluation of magnetic nano materials in vivo and vitro and the unsolved problems in magnetic materials toxicology are also covered.

北京市科委课题

［1］Borm PJA，Kreyling W. Toxicological hazards of inhaled nanoparticles-potential implications for drug delivery［J］. J Nanosci Nanotechnol，2004，4（5）：521-531.
［2］Lam CW, James JT, McCluskey R, et al. Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation［J］. Toxicol Sci，2004，77（1）：126-134.
［3］Tang LP, Hu WJ. Molecular determinants of biocompatibility［J］. Expert Rev Med Devices, 2005, 2(4): 493-500.
［4］Peuster M, Fink C, Reckers J. Assessment of subacute inflammatory and proliferative response to coronary stenting in a porcine model by local gene expression studies and histomorphometry［J］. Biomaterials, 2004, 25(6): 957-963.
［5］Seiler A, Visan A, Buesen R, et al. Improvement of an in vitro stem cell assay for developmental toxicity: the use of molecular endpoints in the embryonic stem cell test［J］. Reprod Toxicol, 2004, 18（2）: 231-240.
［6］Gupta AK, Naregalkar RR, Vaidya VD，et al.Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications［J］.Nanomedicine,2007，2(1)：23-39.
［7］Díaz B, Sánchez-Espinel C, Arruebo M. Assessing methods for blood cell cytotoxic responses to inorganic nanoparticles and nanoparticle aggregates［J］. Small, 2008, 11(4): 2025-2034.
［8］Monteiro-Riviere NA, Inman AO, Zhang LW .Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line［J］.Toxicol Appl Pharmacol,2009, 234(2): 222-235.
［9］Yu KO,  Grabinski CM, Schrand AM，et al. Toxicity of amorphous silica nanoparticles in mouse keratinocytes［J］. J Nanopart Res, 2009, 11(1):15-24.
［10］Mahmoudi M, Shokrgozar M A,  Simchi A， et al .Multiphysics flow modeling and in vitro toxicity of iron oxide nanoparticles coated with poly(vinyl alcohol) ［J］.J Phys Chem C， 2009,113(6):2322-2331.
［11］Kim DH, Kim KN, Kim KM, et al. Targeting to carcinoma cells with chitosan and starch-coated magnetic nanoparticles for magnetic hyperthermia［J］.J Biomed Mater Res A, 2009,88(1):1-11.
［12］Zhang DS, Du YQ. The biocompatibility study of Fe3O4 magnetic nanoparticles used in tumor hyperthermia［M］. Zhuhai: 2006 1st IEEE International Conference on Nano/Micro Engineered and Molecular Systems, 2006, 1(3): 339-342.
［13］Cho M, Cho WS, Choi M, et al. The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles［J］. Toxicol Letters, 2009 (189): 177-183.
［14］Kim JS, Yoon TJ, Yu KN, et al.  Toxicity and tissue distribution of magnetic nanoparticles in mice［J］. Toxicol Sci, 2006, 89(1): 338-347.
［15］Khandoga A，Stampfl A，Takenaka S，et al. Ultrafine particles exert prothrombotic but not inflammatory effects on the hepatic microcirculation in healthy mice in vivo［J］. Circulation，2004，109(10):1320-1325.
［16］Wang TW, Wu HC, Wang WR, et al. The development of magnetic degradable DP-Bioglass for hyperthermia cancer therapy［J］. J Biomed Mater Res A, 2007, 83(3): 828-837.
［17］Park SI, Kim JH, Lim JH, et al.Surface-modified magnetic nanoparticles with lecithin for applications in biomedicine［J］.Current Applied Physics, 2008,8(6):706-709.
［18］Aqil A,Vasseur S, Duguet E, et al. PEO coated magnetic nanoparticles for biomedical application［J］. Eur Polymer J,2008,44(10):3191-3199.
［19］Monteiro-Riviere NA,Inman AO, Zhang LW. Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line［J］. Toxicol  Applied Pharmacol,2009,234(2): 222-235.