目的：研究Annexin A7在胃癌及转移灶中的表达及其临床意义。方法：采用免疫组织化学SP法检测20例正常胃黏膜、60例胃癌原发灶及30例淋巴结转移灶中Annexin A7的表达情况，并比较其与胃癌的不同病理类型、不同分化程度等的关系。结果：Annexin A7在胃癌中阳性率为53.3%，明显高于正常胃黏膜中的25.0%（P<0.05）；在淋巴结转移灶中的阳性率为76.7%，明显高于原发灶的53.3%（P<0.01）。Annexin A7在管状腺癌、黏液腺癌及印戒细胞癌的阳性率分别为63.6%，27.5%及20.0%，其表达在管状腺癌与黏液腺癌之间有统计学差异（P<0.05）。Annexin A7的表达在性别、年龄、肿瘤大小、分化程度及早晚期分组中的差异均无统计学意义（P>0.05）。 结论：Annexin A7高表达在胃癌发生和转移中可能起重要作用；并且其在胃管状腺癌中的表达高于黏液腺癌。

Objective To determine the expression and clinical significance of Annexin A7 in gastric cancer and lymphatic metastasis. MethodsSP immunhistochemical stain was used to examine the expression of Annexin A7 in normal gastric mucosa (n=20), gastric cancer tissue (n=60), and lymphatic metastasis from gastric cancer (n=30). The correlation between Annexin A7 expression and the type of gastric cancer or the degree of tumor differentiation was compared.ResultsThe positive percentage of Annexin A7 expression in cancer tissues was 53.3%, which was significantly higher than that (25.0%) in normal samples (P< 0.05) while significantly lower than that (76.7%) in lymphatic metastasis (P<0.01). The positive percentage of Annexin A7 in tubular adenocarcinoma, mucinous adenocarcinoma, and signet-ring cell carcinoma were 63.6%, 27.5%, and 20.0%, respectively. There was a significant difference between tubular adenocarcinoma and mucinous adenocarcinoma (P<0.05). Gender, age, size of tumor, stage of tumor or the degree of tumor differentiation did not show significant impact on Annexin A7 expression (P>0.05).Conclusion The overexpression of Annexin A7 may play important roles in the development and metastasis of gastric cancer. The expression of Annexin A7 in tubular adenocarcinoma is higher than that in mucinous adenocarcinoma.

国家自然科学基金

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