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国际病理 2008, 28(4) 15-347 DOI:
ISSN: 0412-1961 CN: 21-1139/TG |
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| 综述 |
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调节性树突状细胞的研究进展 |
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刘庆阳1， 姚咏明2， 张淑文1 |
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1. 首都医科大学附属北京友谊医院感染暨急救医学科，北京 100050；2.解放军总医院第一附属医院烧伤研究所，北京 100037 |
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摘要：
树突状细胞（DC）是专职抗原呈递细胞，可将特异性抗原捕获、加工、呈递给淋巴器官，特异性致敏原始T细胞。一群可诱导外周免疫抑制的树突状细胞亚群——调节性树突状细胞(DCregs)，通过诱导T细胞亚群向调节性T细胞（Treg）分化和下调Th1/Th2的比值影响机体免疫状态。获取足量调节性树突状细胞进行过继治疗，可为临床自身免疫病和炎症性疾病的治疗开辟了一条新路。 |
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关键词：
调节性树突状细胞
免疫反应
过继治疗
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Progress in regulatory dendritic cells |
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LIU Qing-yang1, YAO Yong-ming2, ZHANG Shu-wen1
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1.Department of Internal Infectious Disease, Captial University of Medical Sciences, Beijing 100050;
2.Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing 100037，China
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Abstract:
Dendritic cells (DCs) are professional antigen-presenting cells, specialized in the capture, processing, and Tregansport of the antigen to lymphoid organs where they sensitize antigen-specific naive T cells. DCs also have an important role in the control of the adaptive immune response. A subset of DCs-regulatory (DCreg)DCs can lead to the specific differentiation of regulatory T(Treg) cell populations and down-regulation of Th1/Th2. Therefore, the ability to harvesting regulatory DCs opens new therapeutic perspectives for the use of regulatory DCs (DCs cytotherapy) in autoimmune/inflammatory diseases. |
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Keywords:
regulatory dendritic cell
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收稿日期 2007-12-24 修回日期 2008-02-22 网络版发布日期 |
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DOI: |
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基金项目:
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通讯作者: 姚咏明 |
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作者简介: |
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