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国际病理 2008, 28(1) 13-58 DOI:
ISSN: 0412-1961 CN: 21-1139/TG |
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| 综述 |
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肌成纤维细胞在肺纤维化中的来源和作用 |
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杨雪梅，王兴胜;崔社怀 |
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第三军医大学大坪医院野战外科研究所呼吸内科，重庆 400042 |
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摘要：
目前对于肺纤维化（pulmonary fibrosis ，PF）中肌成纤维细胞的来源还不是很清楚，主要有3种假说：肺部原有成纤维细胞转化成为肌成纤维细胞、肺泡上皮细胞穿越基底膜到达纤维化病灶，经上皮-间充质细胞转化为肌成纤维细胞、血液中的纤维细胞到达纤维化病灶转化为肌成纤维细胞等。肌成纤维细胞在PF的病理进程中扮演着重要的角色，其胶原合成能力强可造成细胞外基质的异常沉积、具收缩性使肺顺应性下降、分泌多种炎性介质加重肺泡上皮损伤。 |
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关键词：
肺纤维化
肌成纤维细胞
成纤维细胞
上皮间充质细胞转化
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Origin and role of myofibroblast in pulmonary fibrosis |
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YANG Xue-mei,WANG Xing-sheng, CUI She-huai
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Department of Respiratory Diseases,Research Institute of Surgery, Daping Hospital,Third Military Medical University
of Chinese PLA,Chongqing 400042,China
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Abstract:
The origin of the myofibroblast in the pulmonary fibrosis remains unclear. Three potential sources have been hypothesized： the resident fibroblasts in the lung transform into myofibroblasts; the alveolar epithelial cells traverse basilar membrane and reach the fibrosis focus, and then differentiate into myofibroblasts through a process termed epithelial-mesenchymal transition (EMT); the circulating progenitors derived from bone marrow reach the fibrosis focus and then convert into myofibroblast, and so on. In the pathological proceeding of pulmonary fibrosis, myofibroblast plays an important role, such as: the abnormal extracellular matrix deposition causing by the remarkable capability of collagen synthesis, derogation of the lung compliance owning to the contractibility of myofibroblast,secreting many cytokines,which contribute to the damage of the alveolar epithelial cells. |
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Keywords:
pulmonary fibrosis
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收稿日期 2007-01-17 修回日期 2007-05-20 网络版发布日期 |
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DOI: |
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| 2．曹汐汐;许祖德.Smad与肺纤维化[J]. 国际病理, 2006,26(6): 7-494 |
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