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国际病理 2008, 28(3) 4-204 DOI:
ISSN: 0412-1961 CN: 21-1139/TG |
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| 综述 |
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调节性T细胞免疫效应的调节机制 |
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许长涛1;李为民1， 姚咏明2 |
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1. 解放军总医院第二附属医院肝胆外科， 北京 100091；2. 解放军总医院第一附属医院全军烧伤研究所，北京 100037 |
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摘要：
调节性T细胞(regulatory T cell, Treg)在器官移植、过敏性疾病、肿瘤免疫、感染免疫等病理过程中具有重要作用。Treg通过复杂的作用机制维持外周免疫耐受，限制效应细胞的应答程度，从而防止过度免疫反应所致组织损伤。机体对Treg细胞免疫活性的调节作用及其机制主要包括细胞因子、树突状细胞及共刺激分子、Toll样受体调节机制。 |
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关键词：
调节性T细胞
免疫调节
Toll样受体
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Regulating mechanism of regulatory T cells in
immunoregulatory responses |
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XU Chang-tao1, LI Wei-min1, YAO Yong-ming2
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1.Hepatobiliary Surgery, Second Hospital Affiliated to the Chinese PLA General Hospital, Beijing 100091;
2. Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing 100037, China
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Abstract:
Regulatory T cells (Treg) play an important role in the pathogenesis of organ transplantation, allergic reaction, tumor immunity and infection immunity, etc. It has been demonstrated that Tregs can maintain peripheral immune tolerance by the complicated mechanism to control the extent of cell-mediated immunity and prevent the development of excessive immune-induced tissue damage. The potential role and mechanisms underlying immune system in the process of regulating Tregs include cytokines, dendritic cells, costimulatory molecules and Toll-like receptors. |
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Keywords:
regulatory T cell
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收稿日期 2007-10-21 修回日期 2007-11-19 网络版发布日期 |
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DOI: |
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基金项目:
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通讯作者: 姚咏明 |
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作者简介: |
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