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国际病理 2008, 28(3) 10-235 DOI:
ISSN: 0412-1961 CN: 21-1139/TG |
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| 综述 |
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DNA甲基化和组蛋白乙酰化与胃癌的研究进展 |
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王莉1，戴文香1;苏琦2 |
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南华大学 1.附属第一医院肿瘤内科； 2.肿瘤研究所，湖南 衡阳 421001 |
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摘要：
胃癌是我国最常见的恶性肿瘤，但其具体发病机制还不是很清楚。表遗传学改变，如DNA甲基化和组蛋白修饰改变可以调节基因的表达，在肿瘤的发生和发展中可能起关键作用。近年来一些胃癌相关基因的DNA甲基化和组蛋白乙酰化改变已经得到证实，这些基因改变涉及细胞凋亡、细胞周期阻滞、分化和增殖等。 |
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关键词：
表遗传学
DNA甲基化
组蛋白乙酰化
胃癌
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Advances in study of gastric cancer and DNA
methylation and histone acetylation |
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WANG Li1,DAI Wen-xiang1,SU Qi2
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1. First Affiliated Hospital of Nanhua University;
2. Cancer Research Institute， University of South China, Hengyang Hunan 421001, China
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Abstract:
Gastric cancer is one of the most common malignant tumors, but its pathogenesis is not clear. The changes of epigenetics such as DNA methylation and histone modification can regulate the expression of genes and play an important role in the development of tumors. Recently the genes which were closed correlated with apoptosis, cell cycle arrest, differentiation and proliferation have been detected the changes in DNA methylation and histone acetylation. So this article focused on the research of DNA methylation and histone acetylation and gastric cancer. |
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Keywords:
epigenetics
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收稿日期 2007-11-13 修回日期 2007-12-17 网络版发布日期 |
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DOI: |
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通讯作者: 苏琦 |
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| 本刊中的类似文章 |
| 1．刘丽丽;郭文君. 表遗传修饰对多药耐药基因1调控的研究进展 [J]. 国际病理, 2007,27(3): 14-248 |
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