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国际病理 2009, 29(3) 267-271 DOI:
ISSN: 0412-1961 CN: 21-1139/TG |
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| 综述 |
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神经病理性疼痛的免疫机制 |
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董良综述 郭曲练审校 |
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中南大学湘雅医院麻醉科，长沙 410078 |
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摘要：
研究发现，在中枢神经系统及外周神经系统中，免疫细胞和分子在神经病理性疼痛过程中发挥着越来越重要的作用，对传统的以神经元为中心的疼痛理论发起了挑战。神经损伤后外周的肥大细胞、中性粒细胞、巨噬细胞和T淋巴细胞等免疫细胞所产生的级联炎性反应以及胶质细胞的激活是神经病理性疼痛形成和维持的关键因素，这些免疫细胞通过释放大量炎性介质最终导致疼痛的产生。 |
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关键词：
神经病理性疼痛
神经损伤
免疫
胶质细胞
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Immune mechanism in neuropathic pain |
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DONG Liang, GUO Qulian
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Department of Anesthesioloy, Xiangya Hospital, Central South University, Changsha 410078, China
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Abstract:
It has been shown that immune cells and molecules both in the periphery and the central nervous system play a more and more important role in neuropathic pain, These findings posed a big challenge to the conventional concepts of pain in which neurons were usually thought as the major player. Inflammation reaction involved a cascade of different immune cell types(such as mast cells, neutrophils, macrophages and T lymphocytes) and the the activation of glia cells after nerve damage in the nervous system are crucial for the development and persistence of neuropathic pain. In addition, immune cells and glia release numerous compounds that contribute to pain. In this review we discussed the different immune cell types that contribute to neuropathic pain and the possible underlying mechanisms. |
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Keywords:
neuropathic pain
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收稿日期 2009-01-04 修回日期 2009-01-16 网络版发布日期 |
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DOI: |
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基金项目:
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通讯作者: 郭曲练 |
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