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国际病理 2007, 27(1) 21-88 DOI:
ISSN: 0412-1961 CN: 21-1139/TG |
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| 综述 |
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Rho/Rho激酶信号通路与肺部疾病 |
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邢西迁，甘烨;吴尚洁 |
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中南大学湘雅二医院呼吸内科，长沙 410011 |
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摘要：
Rho通过GTP结合形式和GDP结合形式的转换起着分子开关的作用, 调控许多细胞内信号通路。Rho通过激活其下游靶分子Rho激酶调节细胞的收缩、黏附、迁移、增殖、凋亡等多种生物学行为和功能。目前已证实Rho/Rho激酶通路参与肺动脉高压、哮喘、特发性肺纤维化和肺癌等多种肺部疾病的病理生理过程，在这些疾病的动物模型中阻断该信号通路能够改善这些疾病的病理改变与预后。 |
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关键词：
Rho激酶
肺动脉高压
哮喘
特发性肺纤维化
肺癌
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Rho/Rho-kinase signaling pathway and pulmonary disease |
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XING Xi-qian, GAN Ye, WU Shang-jie
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Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China
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Abstract:
Rho exhibits both GDP/GTP-binding activity and functions as a molecular switch, cycling between a GDP-bound inactive state and a GTP-bound active state. Activated RhoA via its downstream effector Rho-kinase is involved in a wide range of cellular functions, such as cell contraction, adhesion, migration, proliferation and apoptosis. Recently, accumulating evidence has been suggested that activation of the Rho/Rho-kinase signaling pathway is substantially involved in the pathogenesis of several pulmonary diseases, such as pulmonary hypertension, asthma, idiopathic pulmonary fibrosis and lung cancer, while inhibitors of Rho/Rho-kinase signaling pathway can improve the outcome of these diseases in animal models. |
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Keywords:
Rho-kinase
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收稿日期 2006-08-26 修回日期 2006-10-18 网络版发布日期 |
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DOI: |
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| 本刊中的类似文章 |
| 1．邢西迁，甘烨;吴尚洁.Rho激酶与哮喘气道高反应性[J]. 国际病理, 2006,26(6): 9-502 |
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