|
|
国际病理 2009, 29(4) 324-328 DOI:
ISSN: 0412-1961 CN: 21-1139/TG |
|
|
|
|
本期目录 |
下期目录 |
过刊浏览 |
高级检索
[打印本页]
[关闭]
|
|
| 综述 |
|
泛素蛋白酶体系统功能缺陷致帕金森病的机制研究
|
|
|
杨丽1， 吕娥1， 付文玉1， 齐国伟2 |
|
|
1．潍坊医学院组织学与胚胎学教研室，山东 潍坊 261042； 2.周村区第二人民医院妇产科,山东 淄博 255300 |
|
|
摘要：
帕金森病是神经退行性疾病，蛋白酶体抑制剂诱导帕金森病的发病过程更能模拟人类帕金森病的病程进展，中脑黑质多巴胺能神经?坏鱿纸行员湫浴⑷笔В也写嫔窬诨钩鱿諰ewy体，这更符合人类帕金森病的病理特点。因此，泛素蛋白酶体功能缺陷已成为帕金森病发病机制的研究热点。本文将围绕泛素蛋白酶体系统（ubiquitin proteasome system,UPS）的功能、蛋白酶体抑制剂Lactacystin对UPS的作用、泛素蛋白酶体功能缺陷导致多巴胺能神经元损伤的机制展开综述。 |
|
|
关键词：
蛋白酶体抑制剂
帕金森病
小胶质细胞
内质网
线粒体
|
|
|
Mechanism of Parkinson’s disease resulted from
ubiquitin-proteasome system dysfunction |
|
|
YANG Li1, L E1, FU Wenyu1,QI Guowei2
|
|
|
1. Department of Histology and Embryology, Weifang Medical College,Weifang Shandong 261042;
2.Department of Gynecology and Obstertrics, Zhoucun Second People’s Hospital,Zibo Shandong 255300, China
|
|
|
Abstract:
Parkinson’s disease(PD) is a neurodegenerative disease. The proteasome inhibitor-induced PD can simulate the progression of human PD. The dopaminergic neurons in substantia nigra not only showed degeneration and loss but also displayed intracyto- plasmic Lewy body in the survival neurons, which is closely related to the pathological features of human PD. Therefore, ubiquitin-proteasome dysfunction has become the focus for PD study.This article reviewed the function of ubiquitin- proteasome system(UPS), the role of proteasome inhibitor Lactacystin in UPS and the mechanism of defects in dopaminergic neurons resulted from UPS dysfunction. |
|
|
Keywords:
proteasome inhibitor
Parkinson’s disease
microglial cells
endoplasmic reticulum
mitochondria
|
|
|
收稿日期 2009-03-22 修回日期 2009-07-30 网络版发布日期 |
|
|
DOI: |
|
|
基金项目:
|
|
|
通讯作者: 付文玉 |
|
|
作者简介: |
|
作者Email: |
|
|
| 参考文献： |
|
| 本刊中的类似文章 |
|
| 文章评论 |
|
|
|
| Copyright by 国际病理 |
