|
|
国际病理 2009, 29(4) 284-288 DOI:
ISSN: 0412-1961 CN: 21-1139/TG |
|
|
|
|
本期目录 |
下期目录 |
过刊浏览 |
高级检索
[打印本页]
[关闭]
|
|
| 论著 |
|
|
E-cadherin在结直肠癌中的表达及其与侵袭转移的关系 |
|
|
徐胜美, 马红梅，郭东 |
|
|
广东医学院附属福田医院病理科，深圳 518033 |
|
|
摘要：
目的：探讨E-cadherin在结直肠癌（colorectal carcinoma，CRC）中的表达及其与侵袭转移的关系。方法：采用免疫组织化学SABC法及原位杂交技术检测E-cadherin mRNA和蛋白在大肠正常黏膜、大肠腺瘤和CRC组织中的表达。结果： E-cadherin的mRNA和蛋白在CRC中的阳性率显著低于正常黏膜组织和腺瘤（P＜0.01）；随着CRC分化的降低和Dukes分期的增加，E-cadherin表达阳性率降低；E-cadherin的阳性率在有淋巴结和远处器官转移的CRC中均显著低于未转移组（P＜0.01，P＜0.05）。结论：E-cadherin表达减少或缺失在CRC的侵袭转移过程中发挥重要的作用。 |
|
|
关键词：
大肠癌
上皮型钙黏蛋白
免疫组织化学
原位杂交
侵袭转移
|
|
|
Expresssion of E-cadherin in colorectal carcinoma
and the invasion and metastasis |
|
|
XU Shengmei，MA Hongmei，GUO Dong
|
|
|
Department of Pathology,Affiliated Futian Hospital of Guangdong Medical College,Shenzhen 518033,China
|
|
|
Abstract:
Objective To investigate the relation between the invasion and metastasis of colorectal carcinoma and the expression of E-cadherin.MethodsThe immunohistochemistry method and the in situ hybridization method were used to detect the expression of E-cadherin in normal colorectal mucosa，colorectal adenomas，and colorectal carcinomas tissues. ResultsThe positive rate of mRNA and protein of E-cadherin in colorectal carcinoma were lower than that of normal colorectal mucosa and adenomas tissues (P＜0.01); the positive rate of E-cadherin were decreased concomitantly with decrease in differentiation of CRC and the increase in Dukes stages; the positive rate of E-cadherin in colorectal carcinoma of the metastasis of lymph node and distant organ was lower than that of the negative ones(P<0.01，P<0.05).ConclusionThe decrease and absence of E-cadherin play an important role in the invasion and metastasis of colorectal carcinoma. |
|
|
Keywords:
colorectal carcinoma
|
|
|
收稿日期 2009-04-07 修回日期 2009-05-20 网络版发布日期 |
|
|
DOI: |
|
|
基金项目:
|
|
|
通讯作者: 马红梅 |
|
|
作者简介: |
|
作者Email: |
|
|
| 参考文献： |
|
| 本刊中的类似文章 |
| 1．丁杰1;廖国庆2.血管内皮细胞生长因子与大肠癌治疗[J]. 国际病理, 2006,26(6): 3-474 |
| 2．杨莉1，孙明军1，张惠晶1，魏敏杰2，赵海山2.DCC基因在大肠癌中的表达及与Bcl-2, Bax关系[J]. 国际病理, 2008,28(2): 3-107 |
|
| 文章评论 |
|
|
|
| Copyright by 国际病理 |
