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国际病理 2007, 27(4) 5-300 DOI:
ISSN: 0412-1961 CN: 21-1139/TG |
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| 综述 |
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RNA干扰技术在胰腺癌基因治疗中的研究进展 |
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师晓华;梁智勇，刘彤华 |
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中国医学科学院，中国协和医科大学，北京协和医院病理科，北京 100730 |
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摘要：
RNA干扰（RNAi）是生物体内由具有同源性的双链RNA（dsRNA）引发的序列特异的转录后基因沉默。该技术能够快速、高效、特异地抑制靶基因的表达。从1998年发现RNA干扰现象至今，该技术得到了广泛的应用。胰腺癌是一种恶性度高的肿瘤，但是由于各种原因，至今尚无有效的治疗方法。RNA干扰技术是一种十分有前途的基因治疗方法，已广泛应用到胰腺癌的基因治疗研究之中，包括采用RNA干扰技术抑制癌基因、抗凋亡因子；利用RNA干扰技术抑制胰腺癌侵袭、转移蛋白来探讨治疗胰腺癌；利用RNA干扰技术提高胰腺癌对化疗的敏感性等。 |
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关键词：
RNA干扰
胰腺癌
基因治疗
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Application of RNA interference in the gene therapy of pancreatic cancer |
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SHI Xiao-hua, LIANG Zhi-yong, LIU Tong-hua
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Department of Pathology, Peking Union Medical Hospital, Chinese Academy of Medical Science and
Peking Union Medical College, Beijing 100730, China
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Abstract:
RNA interference (RNAi) is a process in which double-stranded RNA triggers the degradation of a homologous messenger RNA, it is also known as post-transcriptional gene silencing (PTGS). This kind of technology develops quickly for it can block the expression of the target gene fast, efficiently and specifically. As we all know, pancreatic cancer is a highly malignant tumor, but yet there are no effective therapy methods. RNAi is considered as a promising gene therapy method, and it has been successfully used to cure the pancreatic cancer, including employing RNAi to suppress the expression of oncogene and anti-apoptotic factors; utilizing RNAi to down-regulated the expression of invasion and metastasis associated protein to cure the pancreatic cancer; using RNAi to improve the chemo sensitivity of pancreatic cancer. |
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Keywords:
RNA interference
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收稿日期 2007-03-07 修回日期 2007-05-17 网络版发布日期 |
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