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国际病理 2009, 29(4) 318-323 DOI:
ISSN: 0412-1961 CN: 21-1139/TG |
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| 综述 |
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吞噬细胞NADPH氧化酶活性的调控 |
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王威 综述 唐圣松审校 |
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南华大学药物药理研究所, 湖南 衡阳 421001 |
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摘要：
吞噬细胞NADPH氧化酶是一个多组分活化的酶复合体，是吞噬细胞抗菌系统的主要成分。此氧化酶体系包括膜结合的和可溶的胞浆蛋白，其主要特征为依赖刺激而活化，机制为复合体的胞浆因子磷酸化并转位至膜，在这里与细胞色素酶相关联，组装完全的复合体在功能上作为一个电子转运体系，从胞浆NADPH转移电子给分子氧形成超氧阴离子（O2-），伴随着接下来的活性物质产生，也叫呼吸爆发，发挥抗菌和抗细胞毒素的活性。NADPH氧化酶的这一活化过程受调节亚基、上游调节子等多重因素的调控。 |
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关键词：
NADPH氧化酶
活性氧
磷酸化
亚基转位
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Regulation of the phagocyte NADPH oxidase activation |
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WANG Wei， TANG Shengsong
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Institude of Phamacy and Phamacology，Nanhua University，Hengyang Hunan 421001, China
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Abstract:
The phagocyte NADPH oxidase is a multicomponent activatable enzyme comprising the major phagocyte antimicrobial systems. The oxidase system includes both membrane-bound and soluble cytosolic proteins. The primary feature of this enzyme is stimulus-dependent activation and which mechanism is the phosphorylation and translocation of a complex of cytosolic factors to the membrane, where they associate with a flavocytochrome enzyme.The fully assembled complex functions as an electron transport system,moving electrons from cytosolic NADPH to molecular oxygen to form superoxide anion（O2-）, which, along with subsequent reactive products called respiratory burst，exerts microbicidal and cytotoxic activities.This activated process of NADPH oxidase is regulated by regulatory subunits，upstream mediators， and the other factors. |
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Keywords:
NADPH oxidase
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收稿日期 2009-04-06 修回日期 2009-05-08 网络版发布日期 |
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DOI: |
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基金项目:
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通讯作者: 唐圣松 |
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| 本刊中的类似文章 |
| 1．冷丽丽,唐圣松.NADPH氧化酶NOX家族的组织分布及生理功能[J]. 国际病理, 2008,28(1): 5-23 |
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