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国际病理 2006, 26(2) 25-184 DOI:
ISSN: 0412-1961 CN: 21-1139/TG |
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| 综述 |
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泛素蛋白酶体通路对Smad通路的影响 |
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李晓照;刘伏友 |
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中南大学湘雅二医院肾脏病研究所， 长沙 410011 |
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摘要：
泛素蛋白酶体通路（UPP）对蛋白稳定性的调控是调节细胞众多生理事件的重要机制，其介导的Smads降解对TGF-β/Smad通路起放大或减弱作用。由于Smad通路是将TGF-β超家族胞外信号传递到核内的主要通路，该通路的调控异常可能参与多种疾病的发生发展。 |
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关键词：
泛素蛋白酶体通路
TGF-β
Smad通路
纤维化
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Ubiquitin-proteasome pathway having an influence
on Smad signaling pathway |
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Li Xiao-zhao， Liu Fu-you
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Research Institute of Nephrology, Second Xiangya Hospital, Central South University, Hunan Changsha， 410011, China
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Abstract:
Ubiquitin-proteasome pathway（UPP）can regulate the stability of proteins，which is regarded as an important mechanism in controlling many physiological events of cells, and the pathway can amplify or weaken TGF-β/Smad signaling pathway through mediating Smads degradation. Because Smad signaling pathway is the main pathway which makes TGF-β superfamily extracellular signaling transmit nucleus, dysfunction regulation of the pathway maybe result in the development of many diseases. |
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Keywords:
ubiquitin-proteasome pathway
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收稿日期 2005-11-18 修回日期 2006-04-03 网络版发布日期 |
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