ObjectiveTo investigate the alteration of some neuro-endocrine-immune indexes in the abnormal savda syndrome tumor model and research the relationship between the abnormal savda syndrome tumor and the disorder of neuro-endocrine-immune. MethodsOne hundred and twenty ICR mice were divided randomly into 4 groups namely control group, tumor group, abnormal savda syndrome model group and abnormal savda syndrome tumor model group. The serum levels of IL-1β, IL-6, TNF-α, ACTH, CORT, DA, and NE were examined by ELISA. ResultsIn the abnormal savda syndrome tumor model group, the rate of tumor transplantation was significantly increased than that of the tumor group, respectively 100% and 63.3% (P<0.01); and the weight of tumor mass was higher in former than in later (P<0.01). Composed with the control group, the serum levels of ACTH both in the abnormal savda syndrome tumor model group and the abnormal savda syndrome group were increased and CORT deceased, IL-6 also increased (P<0.05), but no significant difference between them （P>0.05）. The serum level of TNF-α was raised in abnormal savda syndrome group than that in the tumor group (P<0.05). IL-1β was no significant different among four groups. ConclusionAbnormal savda syndrome body fluid facilitated the development of tumor; it may be related to the disorder of neuro-endocrin-immune.