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国际病理 2007, 27(3) 10-230 DOI:
ISSN: 0412-1961 CN: 21-1139/TG |
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| 综述 |
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SDF-1/CXCR4生物学轴与肿瘤关系的研究进展 |
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陈琼;武明花，李桂源 |
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中南大学肿瘤研究所，长沙 410078 |
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摘要：
趋化因子SDF-1,又称CXCL12,PBSF,与其特异性受体CXCR4广泛表达在多种组织和器官上，它们所构成的SDF-1/CXCR4 生物学轴在多种肿瘤的发生，发展以及转移中都发挥重要作用,其可能是通过MAPK,AKT通路发挥作用。对这一特殊生物学轴的研究可能为肿瘤防治找到新的突破口。 |
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关键词：
SDF-1
CXCR4
肿瘤
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Research progress on SDF-1/CXCR4 axis in tumor |
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CHEN Qiong, WU Ming-hua, LI Gui-yuan
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Cancer Research Institute, Central South University, Changsha 410078, China
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Abstract:
SDF-1(stromal cell- derived factor-1)，also known as CXCL12,PBSF,is a member of CXC sub-family chemokines. Various tumor cells express chemokine SDF-1 and it’s receptor CXCR4, and they constitute a special biological axis of SDF-1/CXCR4,which is closely related to development and metastasis of tumor cells through MAPK or Akt signaling pathway. Research on this axis may provide a wide clinical application in the prevention and treatment of tumor. |
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Keywords:
SDF-1
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收稿日期 2006-12-28 修回日期 2007-01-11 网络版发布日期 |
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