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国际病理 2009, 29(1) 69-72 DOI:
ISSN: 0412-1961 CN: 21-1139/TG |
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| 综述 |
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FcγR与自身免疫性疾病的相关性及免疫靶向干预治疗 |
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薛渊综述 许化溪 审校 |
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江苏大学检验医学研究所免疫学研究室，江苏 镇江 212013 |
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摘要：
IgG Fc受体（FcγR）是免疫应答中重要的膜性调节分子，表达于几乎所有白细胞的表面，是连接体液免疫和细胞免疫的桥梁。FcγR不仅介导免疫细胞的活化和效应的发挥，而且在特定条件下参与免疫损伤，构成某些免疫相关性疾病的病理机制。近年来，FcγR及其基因多态性在自身免疫性疾病发生发展中的作用及免疫靶向干预引起了国内外学者的关注。 |
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关键词：
FcγR
基因多态性
免疫相关性疾病
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Relation between FcγR and autoimmune diseases and
targeted therapy by FcγR |
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XUE Yuan, XU Huaxi
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Department of Immunology, Institute of Clinical Laboratory Medicine,Jiangsu University，Zhenjiang Jiangsu 212013, China
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Abstract:
IgG Fc receptor（FcγR）, expressed on the surface of most leukocytes,is an important immunoregulatory molecule. FcγR plays an important role both in cell immunity and humoral immunity. On certain circumstances, FcγR may cause immune damage to the body. Recently, plenty of researches have shown that FcγR genetic polymorphism is related to the pathogenesis of autoimmune diseases. In this review, we summarized the role of FcγR and its targeting intervene in immune diseases. |
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Keywords:
FcγR
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收稿日期 2008-06-26 修回日期 2008-10-22 网络版发布日期 |
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