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国际病理 2007, 27(6) 5-488 DOI:
ISSN: 0412-1961 CN: 21-1139/TG |
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| 综述 |
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Cyr61与消化系统肿瘤侵袭和转移的关系 |
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马海芬1，2;赵仲生3 |
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1.温州医学院研究生部，浙江 温州 325035； 2.浙江省人民医院病理科， 杭州 310014；
3.宁波市北仑区宗瑞医院病理科，浙江 宁波 315806 |
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摘要：
Cyr61(cysteine-rich 61)是CCN家族成员之一，可与肝素和多种整联蛋白结合，刺激细胞增殖、趋化、黏附，诱导血管发生，参与炎症反应、伤口愈合和组织重塑过程，与多种肿瘤的发生发展有关。在食管腺癌、胃癌、结直肠癌、肝癌、胰腺癌等消化系肿瘤中起促进肿瘤细胞侵袭和转移的重要作用。开展消化系肿瘤Cyr61基因的检测，为评估病人的预后提供了新的依据。 |
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关键词：
Cyr61
消化系肿瘤
侵袭
转移
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Significance of Cyr61 in digestive system
neoplasms invasion and metastasis |
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MA Hai-fen1，2， ZHAO Zhong-sheng3
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1.Department of Graduate, Wenzhou Medical College，Wenzhou Zhejiang，325035；
2.Department of Pathology，Zhejiang Provincial Hospital，Hangzhou 310014;
3.Department of Pathology，Ningbo Zongrui Hospital，Ningbo Zhejiang，315806 China
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Abstract:
Cyr61 is one of the CNN family members, binding with heparin and a variety of integrins, promoting the cellular behaviors such as proliferation, chemotaxis, adhesion, inducing angiogenesis, participating in inflammation, wound healing and tissue remodeling. Correlating with tumor genesis and development, Cyr61 may play an important role by promoting tumor cell invasion and metastasis in digestive system neoplasms, such as oesophageal adenocarcinoma, gastric cancer, colorectal cancer, hepatocellular carcinoma and pancreatic cancer. The gene detection of Cyr61 may serve as a new prognostic maker of digestive system neoplasms. |
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Keywords:
yr61
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收稿日期 2007-04-10 修回日期 2007-07-10 网络版发布日期 |
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DOI: |
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基金项目:
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通讯作者: 赵仲生 |
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作者简介: |
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