|
|
国际病理 2006, 26(2) 5-112 DOI:
ISSN: 0412-1961 CN: 21-1139/TG |
|
|
|
|
本期目录 |
下期目录 |
过刊浏览 |
高级检索
[打印本页]
[关闭]
|
|
| 综述 |
|
|
过氧化物酶体增殖物激活受体-γ与肿瘤 |
|
|
黄垂学;刘运生 |
|
|
中南大学湘雅医院神经外科，长沙 410008 |
|
|
摘要：
PPAR-γ是一种细胞核转录因子，与糖代谢调节、脂肪细胞分化相关。其配体除了具有改善胰岛素抵抗和血脂、免疫调节和抗炎作用外，还具有抗肿瘤细胞增殖和促细胞分化作用，对肿瘤细胞的转移、侵袭等生物学行为也有影响。其机制可能是诱导细胞周期停滞和凋亡，促进细胞分化，通过抑制NF-κB活性和阻断EGFR信号通路起抑制肿瘤细胞生长的作用 |
|
|
关键词：
PPAR-γ
肿瘤
脑肿瘤
|
|
|
Peroxysome proliferator-activated receptor-γ
and human tumors |
|
|
HUANG Chui-xue， LIU Yun-sheng
|
|
|
Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China
|
|
|
Abstract:
Peroxysome proliferator-activated receptor-γ (PPAR-γ) is the member of the nuclear receptor superfamily and functions as a transcription factor mediating ligand-dependent transcriptional regulation. Its activation is associated with glucose metabolism regulation, lipocyte differentiation. Except for the effects including improving insulin resistance and plasm lipid, immunomodulation and anti-inflammatory, PPAR-γ ligands can inhibit proliferation and induce differentiation of several cancer cells, moreover exert an influence on the invasive and metastatic potential of cancer cells. The possible mechanisms by which PPAR-γ ligands exert their anticancer effect may be the induction of cell cycle arrest and apoptosis, the induction of cell differentiation, and the inhibition of NF-κB and blockage of EGFR signal pathway. |
|
|
Keywords:
PPAR-γ
tumor
brain tumor
|
|
|
收稿日期 2005-11-09 修回日期 2006-02-23 网络版发布日期 |
|
|
DOI: |
|
|
基金项目:
|
|
|
通讯作者: |
|
|
作者简介: |
|
作者Email: |
|
|
| 参考文献： |
|
| 本刊中的类似文章 |
|
| 文章评论 |
|
|
|
| Copyright by 国际病理 |
