Multidrug resistance(MDR) is a mostly causation of chemotherapy failing in leukaemia. Nuclear factor κappa-B (NF-κB) is an important nuclear transcription gene which consists in cells abroadly in vivo. NF-κB are not only concerned with regulation of inflammation and immunity genes, but also resist in apoptosis via adjusting the gene of cell proliferation and cell process death. Anticancer drug killed the tumour cell, at the same time also activated NF-κB, which lead to the tumour cell drug resistance through increasing the expression of MDR gene. To restrain the activity of NF-κB moderately can control multidrug resistance of tumour cell, and improve chemotherapy effect in leukaemia.