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国际病理 2009, 29(1) 77-81 DOI:
ISSN: 0412-1961 CN: 21-1139/TG |
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| 综述 |
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Caveolae与胰岛素抵抗 |
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赵玮综述 王绵 审校 |
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河北医科大学第二医院内分泌科，石家庄 050000 |
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摘要：
Caveolae（小凹结构）是细胞质膜上一种富含胆固醇和鞘脂的特异性囊状结构脂筏。近年来研究发现其特异蛋白Caveolins（小窝蛋白）与胰岛素抵抗关系密切。Caveolins通过与胰岛素受体相互作用，参与体内葡萄糖、脂肪代谢等方面来调节胰岛素敏感性，是治疗糖尿病的新位点。 |
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关键词：
小凹结构
小窝蛋白
胰岛素抵抗
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Caveolae and insulin resistance |
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ZHAO Wei, WANG Mian
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Department of Endocrinology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
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Abstract:
Caveolae is a kind of specific capsular structural lipid raft located in plasma membrane which riches in cholesterol and sphingolipid. Recently, some reports indicated that there is a close relationship between its specific protein caveolins and insulin resistance. Caveolins regulate insulin sensitivity by interacting with the insulin receptor, participating in glucose and fat metabolism， and may be it’s a new treatment site of diabetes. |
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Keywords:
caveolae
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收稿日期 2008-12-05 修回日期 2009-01-07 网络版发布日期 |
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DOI: |
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基金项目:
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通讯作者: 王绵 |
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