|
|
国际病理 2009, 29(1) 37-40 DOI:
ISSN: 0412-1961 CN: 21-1139/TG |
|
|
|
|
本期目录 |
下期目录 |
过刊浏览 |
高级检索
[打印本页]
[关闭]
|
|
| 综述 |
|
|
Toll样受体3在病毒感染及细胞凋亡中的生物学功能 |
|
|
孙瑞利, 张 宇综述 胡锦跃 审校 |
|
|
中南大学肿瘤研究所, 长沙 410078 |
|
|
摘要：
Toll样受体3（TLR3）作?《舅碦NA识别受体在机体抗病毒天然免疫中发挥十分重要的作用。TLR3识别配体后通过含TIR结构域的转接蛋白（TRIF）途径活化转录因子NF-κB和干扰素调节因子3（IRF3），诱导炎症细胞释放炎症因子并介导炎症反应，同时诱导I型干扰素的释放,介导抗病毒天然免疫。在一些病毒感染中TLR3通过诱导组织损伤介导病毒的扩散从而加重疾病的严重程度。部分肿瘤细胞也表达TLR3，活化的TLR3介导细胞凋亡、抑制细胞增殖，提示TLR3可能是肿瘤免疫治疗的新靶点。［关键词］ Toll样受体3；信号转导；病毒；肿瘤；细胞凋亡 |
|
|
关键词：
Toll样受体3
信号转导
病毒
肿瘤
细胞凋亡
|
|
|
Biologic functions of Toll-like receptor 3 for
virus infection and cell apoptosis |
|
|
SUN Ruili, ZHANG Yu, HU Jinyue
|
|
|
Cancer Research Institute, Central South University, Changsha 410078, China
|
|
|
Abstract:
Toll-like receptor 3 (TLR3), the receptor recognizing virus double-strain RNA, plays important roles in the anti-virus innate immunity. By binding its ligands, TLR3 activates transcriptional factor NF-κB and interferon regulatory factor 3(IRF3) via myeloid differentiation factor 88(MyD88) independent but TIR-domain-containing adaptor protein inducing IFN-β(TRIF) dependent pathway, leading to the production of pro-inflammatory factors to elicit the inflammatory response, and the production of type I interferon to trigger the anti-virus innate immunity. The results in recent studies show that in some virus infection the activation of TLR3 results in virus dissemination, thus leading to promote the progress of the disease. In addition, a part of tumor cells express TLR3. The activation of TLR3 in tumor cells leads to the cell apoptosis, and the inhibition of cell growth, suggesting that TLR3 maybe a new target for tumor immune therapy. |
|
|
Keywords:
Toll-like receptor 3
|
|
|
收稿日期 2008-09-10 修回日期 2008-10-10 网络版发布日期 |
|
|
DOI: |
|
|
基金项目:
|
|
|
通讯作者: 胡锦跃 |
|
|
作者简介: |
|
作者Email: |
|
|
| 参考文献： |
|
| 本刊中的类似文章 |
|
| 文章评论 |
|
|
|
| Copyright by 国际病理 |
