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国际病理 2006, 26(3) 20-262 DOI:
ISSN: 0412-1961 CN: 21-1139/TG |
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| 综述 |
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HLA-G多态性在生殖领域的研究进展 |
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马薇1,2;周昌菊1 |
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1.中南大学湘雅三医院妇产科,长沙 410013； 2.西北民族大学医学院，兰州 730030 |
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摘要：
正常的妊娠维持为母体对胎儿的免疫耐受。HLA-G作为一种人类的主要组织相容性复合体，具有限多态性。HLA-G多态性与胚胎的早期发育、IVF妊娠结局、正常妊娠维持、多种妊娠相关疾病及妊娠并发症（如复发性流产、子痫前期）的发生发展密切相关。 |
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关键词：
HLA-G多态性
胚胎的早期发育
IVF妊娠结局
正常妊娠维持
妊娠并发症
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Research progression of HLA-G polymorphism in human reproduction |
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MA Wei1,2, ZHOU Chang-ju1
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1.Department of Obstetrics and Gynecology, Third Xiangya Hospital, Central South University, Changsha 410013;
2.Medical College of Northwest Nationality University, Lanzhou 730030， China
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Abstract:
Normal pregnancy depends on materno-fetal tolerance. Human leukocyte antigen (HLA)-G is the non-classical human major histocompatibility complex (MHC), having limited polymorphism. HLA-G polymorphism may be related to embryo early development, IVF pregnancy outcome, normal pregnancy maintenance, and certain complications of pregnancy such as pre-eclampsia and recurrent spontaneous abortions (RSA). |
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Keywords:
HLA-G polymorphism
embryo early development
IVF pregnancy outcome
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收稿日期 2005-11-09 修回日期 2006-04-17 网络版发布日期 |
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