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国际病理 2006, 26(6) 7-494 DOI:
ISSN: 0412-1961 CN: 21-1139/TG |
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| 综述 |
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Smad与肺纤维化 |
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曹汐汐;许祖德 |
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复旦大学上海医学院病理学系，上海 200032 |
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摘要：
转化生长因子β(TGF-β) 是与肺纤维化关系较为密切的细胞因子。Smad蛋白为TGF-β受体后下游的主要信号转导因子,其中Smad3是纤维化疾病的重要介导者,Smad7是TGF-β信号转导途径的主要抑制性蛋白,它们的异常表达可影响TGF-β活性,进而改变纤维化进程。调控Smad3，Smad7的表达可能为治疗纤维化疾病提供一种新手段。 |
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关键词：
Smad蛋白
转化生长因子β
肺纤维化
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Smads and pulmonary fibrosis |
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CAO Xi-xi, XU Zu-de
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Department of Pathology, Shanghai Medical College of Fudan University, Shanghai 200032, China
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Abstract:
Transforming growth factor-β(TGF-β) plays a central role in pulmonary fibrosis. The Smads act the downstream of receptors for the transforming growth factor-β family of ligands, among which Smad3 functions as a mediator of fibrotic disorder, while Smad7 is a major inhibitory regular in TGF-β signaling pathway. The abnormal expression of Smad3 or Smad7 can affect the activity of TGF-β and accordingly change the process of fibrosis. The modulation of Smad3 or Smad7 expression may have tremendous clinical potential in therapeutic strategy for fibrotic diseases. |
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Keywords:
Smads
TGF-β
pulmonary fibrosis
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收稿日期 2006-07-10 修回日期 2006-10-23 网络版发布日期 |
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