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国际病理 2008, 28(5) 9-411 DOI:
ISSN: 0412-1961 CN: 21-1139/TG |
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| 综述 |
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容积调控性氯离子通道与肿瘤 |
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李敏1,王玲玲2，焦雪娟2综述 王波1 审校 |
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1.山东大学齐鲁医院妇产科，济南 250012； 2.蚌埠医学院附属医院妇产科,安徽 蚌埠 233004 |
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摘要：
容积调控性氯通道在细胞的容积调节、增殖及凋亡等生理过程中发挥重要作用，其分子结构尚未确定。近年研究发现容积调控性氯通道与肿瘤细胞的增殖、侵袭、迁移、凋亡及多药耐药性等恶性生物学行为有关。随着研究深入，容积调控性氯通道将成为抗肿瘤治疗的新靶点。 |
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关键词：
氯离子通道
肿瘤
增殖
迁移
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Volume-regulated chloride channels and neoplasm |
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LI Min1, WANG Ling-ling2, JIAO Xue-juan2, WANG Bo1
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1.Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan 250012;
2.Department of Obstetrics and Gynecology, Hospital Affiliated Bengbu Medical College, Bengbu Anhui 233004, China
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Abstract:
Volume-regulated chloride channels play a significant role in the cell volume regulation, proliferation and apoptosis in many cell types. The molecular identification, however, has not been determined. In recent years, it has been realized that volume-regulated chloride channels are closely associated with proliferation, invasion, migration, apoptosis and multidrug resistance of tumor cells. Therefore, volume-regulated channels may be a useful anticancer target in the future. |
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Keywords:
chloride channels
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收稿日期 2008-05-12 修回日期 2008-07-28 网络版发布日期 |
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