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国际病理 2009, 29(2) 115-120 DOI:
ISSN: 0412-1961 CN: 21-1139/TG |
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| 综述 |
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细胞穿透肽穿膜机制的研究进展 |
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陈茜1，刘亚伟2，黄邵2 ，杨勤1 综述 姜勇2审校 |
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1.贵阳医学院病理生理学教研室，贵阳 550004; 2.南方医科大学病理生理学教研室， 广州 510515 |
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摘要：
细胞穿透肽是一类少于30个氨基酸的短肽,它们能穿过细胞膜并携带各种“货物”包括小分子、蛋白、肽、核酸等进入细胞，而发挥“货物”的生物学作用。其转导机制一直是研究的热点，至今仍不明确。本文讨论直接入胞、转导、内吞3种可能的穿膜机制及其特点。 |
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关键词：
细胞穿透肽
跨膜转运机制
内吞
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Advances in mechanisms of internalization of cell-penetrating peptides |
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CHEN Xi1, LIU Yawei2, HUANG Shao2, YANG Qin1, JIANG Yong2
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1.Department of Pathophysiology, Guiyang Medical College, Guizhou 550004;
2. Department of Pathophysiology, Southern Medical University, Guangzhou 510515, China)
［Abstract］Cell-penetrating peptides are relatively short domain of the peptides sequence (fewer than 30 amino acid residue
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Abstract:
Cell-penetrating peptides are relatively short domain of the peptides sequence (fewer than 30 amino acid residue ). They can cross cell membranes and deliver a large variety of biological cargoes, such as small particles, protein, peptides, and nucleic acids，and induce the biological effects of cargoes. The uptake mechanism of cell-penetrating peptides is currently a topic of heated discussion, which is not clear yet. This review briefly discusses 3 possible uptake mechanisms and the characteristics: direct penetration into the membrane, translocation through formation of a transient structure,endocytosis-mediated entry. |
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Keywords:
cell-penetrating peptides
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收稿日期 2008-11-06 修回日期 2009-04-07 网络版发布日期 |
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DOI: |
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基金项目:
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通讯作者: 姜勇 |
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