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国际病理 2008, 28(5) 19-455 DOI:
ISSN: 0412-1961 CN: 21-1139/TG |
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| 综述 |
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脂联素对糖尿病大血管病变的影响 |
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董源媛综述 肖新华 审校 |
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南华大学附属第一医院内分泌科，湖南 衡阳 421001 |
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摘要：
脂联素(adiponectin，APN)是脂肪细胞分泌的一种细胞因子，通过结合APN受体1和受体2发挥抗炎、抗糖尿病、抗动脉粥样硬化的作用。1型糖尿病病人和正常人的血清APN水平相似，但2型糖尿病病人的APN水平显著降低。2型糖尿病的心血管并发症明显增加，且2型糖尿病合并心血管病变患者的APN水平明显低于2型糖尿病但无心血管病变者，提示糖尿病大血管病变可能与APN缺乏有关。 |
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关键词：
脂联素
脂联素受体
糖尿病
大血管病变
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Effect of adiponectin on diabetic macro-angiopathy |
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DONG Yuan-yuan, XIAO Xin-hua
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Department of Endocrinology & Metabolism， jFirst Affiliated Hospital of Nanhua University， Hengyang Hunan 421001, China
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Abstract:
Adiponectin (APN) is an adipocyte secreting cytokine, which exerts anti-inflammatory, anti-diabetic,and anti-atherosclerotic effects via combining with adiponectin receptor-l and 2. The serum adiponectin concentration is similar between type 1 diabetes and normal, but significantly decreased in type 2 diabetes. Cardiovascular complications are evidently augmented in patients with type 2 diabetes. APN levels are significantly lower in cases of cardiovascular diseases combined with type 2 diabetes than those without type 2 diabetes, suggesting that macro-vascular lesions may be related to the lack of APN. Illustrating the mechanism of APN effect on macro-vascular may contribute to provide a new idea that macro-angiopathy is less in type 1 diabetes compare to type 2 diabetes, even though blood glucose fluctuate in a large range. |
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Keywords:
adiopnectin
adiopnectin receptor
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收稿日期 2008-04-23 修回日期 2008-05-29 网络版发布日期 |
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